Technetium-99m-HMPAO brain SPECT in neonates with hypoglycemic encephalopathy

Nan Tsing Chiu, Chao Ching Huang, Ying Chao Chang, Chyi Her Lin, Wei Jen Yao, Chin Yin Yu

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)


Regional brain injury in three neonates with hypoglycemic encephalopathy are presented using serial 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT and, for comparison, MRI. During the acute stage, both 99mTc-HMPAO SPECT and MRI reveal abnormalities in the posterior cerebrum. Technetium- 99m-HMPAO SPECT reveals further areas of insult, for example the frontal lobes. The degree of hypoperfusion correlates with the clinical severity of hypoglycemia during the neonatal period and subsequent neurological sequelae. Follow-up with HMPAO SPECT several months after insult demonstrates persistent hypoperfusion in some areas, mainly in the occipital and posterior parietal regions. MRI can depict morphological changes with superior resolution. Because morphological change generally follows slowly after functional change, MRI is less sensitive than HMPAO SPECT in detecting and predicting the extent of hypoglycemic cerebral injury during the acute phase. HMPAO SPECT during the acute stage is a valuable tool for evaluating the extent and severity of brain injury in neonates with hypoglycemic encephalopathy.

頁(從 - 到)1711-1713
期刊Journal of Nuclear Medicine
出版狀態已發佈 - 10月 1998

ASJC Scopus subject areas

  • 放射與超音波技術


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