Targeting Nanocarriers Combined with Photothermal Thrombolytic Therapy Tested from In Vitro, and Thrombosis Vessel-On-A-Chip, to In Vivo

Kuan Ting Liu, Er Yuan Chuang, Yu Jui Fan, Jiashing Yu

研究成果: 書貢獻/報告類型會議貢獻

摘要

In this study, we proposed a thrombosis vessel-on-a-chip microfluidic model for thrombosis-related targeted nanoparticles (NPs) evaluation. Assessments with human blood flow and inflammatory endothelium confirmed its highly precise homing to activated thrombus microenvironments and efficient near infrared-phototherapeutic effects at thrombus lesions under a physiological flow environment ex vivo. Its clot lysis performance in a microfluidic system was comparable to that of an in vivo model experiment. This combined experimental, microfluidic, and in vivo work confirms the potential of (GCPIH) NPs for thrombus therapy and presents a promising platform to develop thrombolytic nanomedicines.
原文英語
主出版物標題2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
發行者Institute of Electrical and Electronics Engineers Inc.
頁面229-231
頁數3
ISBN(電子)9784886864352
出版狀態已發佈 - 2023
事件22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 - Kyoto, 日本
持續時間: 6月 25 20236月 29 2023

出版系列

名字2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

會議

會議22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
國家/地區日本
城市Kyoto
期間6/25/236/29/23

ASJC Scopus subject areas

  • 電腦科學應用
  • 電氣與電子工程
  • 控制和優化
  • 儀器

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