Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan

Hsien Yu Fan, Wan Yu Lin, Tzu Pin Lu, Yun Yu Chen, Justin Bo Kai Hsu, Sung Liang Yu, Ta Chen Su, Hung Ju Lin, Yang Ching Chen, Kuo Liong Chien

研究成果: 雜誌貢獻文章同行評審

摘要

Background: Left ventricular mass is a highly heritable disease. Previous studies have suggested common genetic variants to be associated with left ventricular mass; however, the roles of rare variants are still unknown. We performed targeted next-generation sequencing using the TruSight Cardio panel, which provides comprehensive coverage of 175 genes with known associations to 17 inherited cardiac conditions. Methods: We conducted next-generation sequencing using the Illumina TruSight Cardiomyopathy Target Genes platform using the 5% and 95% extreme values of left ventricular mass from community-based participants. After removing poor-quality next-generation sequencing subjects, including call rate
原文英語
文章編號1064980
期刊Frontiers in Genetics
13
DOIs
出版狀態已發佈 - 1月 12 2023

ASJC Scopus subject areas

  • 分子醫學
  • 遺傳學
  • 遺傳學(臨床)

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