Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

Tso Hsiao Chen; Yu Tern Hsu; Cheng Hsien Chen; Shu Hwei Kao; Horng Mo Lee

doi:10.1016/j.mito.2006.11.018

Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

Tso Hsiao Chen, Yu Tern Hsu, Cheng Hsien Chen, Shu Hwei Kao, Horng Mo Lee

研究成果: 雜誌貢獻 › 文章 › 同行評審

61 引文斯高帕斯（Scopus）

摘要

Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.

原文	英語
頁（從 - 到）	101-105
頁數	5
期刊	Mitochondrion
卷	7
發行號	1-2
DOIs	https://doi.org/10.1016/j.mito.2006.11.018
出版狀態	已發佈 - 2月 2007

ASJC Scopus subject areas

分子醫學
分子生物學
細胞生物學

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10.1016/j.mito.2006.11.018

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title = "Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells",

abstract = "Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.",

keywords = "Cyclooxygenase-2, Heme oxygenase-1, RAW 264.7 macrophages, Tanshinone IIA",

author = "Chen, {Tso Hsiao} and Hsu, {Yu Tern} and Chen, {Cheng Hsien} and Kao, {Shu Hwei} and Lee, {Horng Mo}",

year = "2007",

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doi = "10.1016/j.mito.2006.11.018",

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AU - Chen, Tso Hsiao

AU - Hsu, Yu Tern

AU - Chen, Cheng Hsien

AU - Kao, Shu Hwei

AU - Lee, Horng Mo

PY - 2007/2

Y1 - 2007/2

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KW - Heme oxygenase-1

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Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

摘要

ASJC Scopus subject areas

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