T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Leroy F. Liu, Chung Cheng Liu, Bruce M. Alberts

研究成果: 雜誌貢獻文章同行評審

170 引文 斯高帕斯(Scopus)

摘要

A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

原文英語
頁(從 - 到)456-461
頁數6
期刊Nature
281
發行號5731
DOIs
出版狀態已發佈 - 1979
對外發佈

ASJC Scopus subject areas

  • 多學科

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