T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy

L. V. Abruzzo, E. S. Jaffe, J. D. Cotelingam, J. Whang-Peng, V. Del Duca, L. J. Medeiros

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108 引文 斯高帕斯(Scopus)


Three patients with T-cell lymphoblastic lymphoma and peripheral blood eosinophilia are reported. At the time of diagnosis, all patients had lymphadenopathy, and one had a mediastinal mass. Lymph node biopsies revealed lymphoblastic lymphoma admixed with a variable number of mature eosinophils. Immunophenotypic studies demonstrated that each lymphoma had an immature T- cell immunophenotype. Bone marrow biopsies were hypercellular with myeloid hyperplasia and eosinophilia but were negative for lymphoma. All patients received multiagent chemotherapy; one patient achieved a complete remission, and two patients had partial remissions. All patients subsequently developed a myeloid malignancy. Two died of acute myeloid leukemia within 18 months of the diagnosis of lymphoblastic lymphoma. The third patient relapsed with a lymphoma that had histologic and immunophenotypic features of both T-cell lymphoblastic lymphoma and granulocytic sarcoma and also developed a poorly defined myeloproliferative disorder. These findings suggest that T-cell lymphoblastic lymphoma associated with eosinophilia may represent a distinct clinicopathologic entity with a high risk of subsequent myeloid neoplasia.
頁(從 - 到)236-245
期刊American Journal of Surgical Pathology
出版狀態已發佈 - 1月 1 1992

ASJC Scopus subject areas

  • 解剖學
  • 手術
  • 病理學與法醫學


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