Systemic sclerosis and the risk of tuberculosis

Shuo Ming Ou, Wen Chien Fan, Kun Ta Cho, Chiu Mei Yeh, Vincent Yi Fong Su, Man Hsin Hung, Yu Sheng Chang, Yi Jung Lee, Yung Tai Chen, Pei Wen Chao, Wu Chang Yang, Tzeng Ji Chen, Wei Shu Wang, Hsuan Ming Tsao, Li Fu Chen, Fa Yauh Lee, Chia Jen Liu

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)


Objective: Pulmonary involvement is common in patients with systemic sclerosis (SSc), and this condition causes substantial morbidity and mortality. Disrupted immunity from the disease or associated medication may render such patients subject to tuberculosis (TB) infection. However, the relationship between SSc and TB has not yet been investigated. Methods: Using the Taiwan National Health Insurance Research Database, 838 patients with SSc diagnosed in Taiwan during 2000-2006 were identified and followed for emergence of TB infection. Incidence rate ratios (IRR) of TB compared to 8380 randomly selected age-, sex-, and comorbiditymatched controls without SSc were calculated. The Cox proportional hazards model was used for multivariate adjustment to identify independent risk factors for TB infection. Results: The risk of TB infection was higher in the SSc cohort than in controls (IRR 2.81, 95% CI 1.36-5.37; p = 0.004), particularly for pulmonary TB (IRR 2.53, 95% CI 1.08-5.30; p = 0.022). Other independent risk factors for TB infection in patients with SSc were age =≥ 60 years [hazard ratio (HR) 3.52, 95% CI 1.10-11.33; p = 0.035] and pulmonary hypertension (PH; HR 6.06, 95% CI 1.59-23.17; p = 0.008). Mortality did not differ for SSc patients with or without TB. Conclusion: In this nationwide study, the incidence of TB infection was significantly higher among patients with SSc than in controls without SSc. Special care should be taken in managing patients with SSc who are at high risk for TB, especially those aged = 60 years or who also have PH.
頁(從 - 到)1662-1669
期刊Journal of Rheumatology
出版狀態已發佈 - 8月 2014

ASJC Scopus subject areas

  • 免疫學和過敏
  • 風濕病
  • 免疫學


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