Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants

Yves S.Y. Hsieh, Brendan L. Wilkinson, Mitchell R. O'Connell, Joel P. MacKay, Jacqueline M. Matthews, Richard J. Payne

研究成果: 雜誌貢獻文章同行評審

41 引文 斯高帕斯(Scopus)

摘要

The synthesis of sublancin 168, a unique S-glucosylated bacteriocin antibiotic, is described. The natural product and two S-glycosylated variants were successfully prepared via native chemical ligation followed by folding. The synthetic glycopeptides were shown to possess primarily an α-helical secondary structure by CD and NMR studies.

原文英語
頁(從 - 到)1910-1913
頁數4
期刊Organic Letters
14
發行號7
DOIs
出版狀態已發佈 - 4月 6 2012
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

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