Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen; T. H. Li; S. M. Song; Y. C. Liao; P. H. Tsai; P. C. Wong; V. C. Nguyen; J. S.C. Jang

doi:10.1016/j.matlet.2019.126650

Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen, T. H. Li, S. M. Song, Y. C. Liao, P. H. Tsai, P. C. Wong, V. C. Nguyen, J. S.C. Jang

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11 引文斯高帕斯（Scopus）

摘要

A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

原文	英語
文章編號	126650
期刊	Materials Letters
卷	256
DOIs	https://doi.org/10.1016/j.matlet.2019.126650
出版狀態	已發佈 - 12月 2019

ASJC Scopus subject areas

一般材料科學
凝聚態物理學
材料力學
機械工業

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10.1016/j.matlet.2019.126650

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title = "Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application",

abstract = "A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.",

keywords = "Amorphous materials, Biomaterials, Hot-pressing, Mechanical property, Porous materials",

author = "Nguyen, {V. T.} and Li, {T. H.} and Song, {S. M.} and Liao, {Y. C.} and Tsai, {P. H.} and Wong, {P. C.} and Nguyen, {V. C.} and Jang, {J. S.C.}",

note = "Funding Information: The authors gratefully acknowledge the sponsorship provided by the Ministry of Science and Technology of ROC under the projects MOST105-2221-E-008 -025 -MY3 and MOST 106-3114-E-110-003. In addition, the authors gratefully acknowledge the help from the Precision Instrument Center of Engineering College, NCU, for the SEM and TEM characterizations and Wallace Academic Editing for revising this manuscript. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

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AU - Nguyen, V. T.

AU - Li, T. H.

AU - Song, S. M.

AU - Liao, Y. C.

AU - Tsai, P. H.

AU - Wong, P. C.

AU - Nguyen, V. C.

AU - Jang, J. S.C.

N1 - Funding Information: The authors gratefully acknowledge the sponsorship provided by the Ministry of Science and Technology of ROC under the projects MOST105-2221-E-008 -025 -MY3 and MOST 106-3114-E-110-003. In addition, the authors gratefully acknowledge the help from the Precision Instrument Center of Engineering College, NCU, for the SEM and TEM characterizations and Wallace Academic Editing for revising this manuscript. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/12

Y1 - 2019/12

N2 - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

AB - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

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KW - Biomaterials

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KW - Porous materials

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Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

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