Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

Der Zen Liu; Supachok Sinchaikul; Peddiahgari Vasu Govardhana Reddy; Meng Yang Chang; Shui Tein Chen

doi:10.1016/j.bmcl.2006.11.008

Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

Der Zen Liu, Supachok Sinchaikul, Peddiahgari Vasu Govardhana Reddy, Meng Yang Chang, Shui Tein Chen

研究成果: 雜誌貢獻 › 文章 › 同行評審

48 引文斯高帕斯（Scopus）

摘要

A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.

原文	英語
頁（從 - 到）	617-620
頁數	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	17
發行號	3
DOIs	https://doi.org/10.1016/j.bmcl.2006.11.008
出版狀態	已發佈 - 2月 1 2007

ASJC Scopus subject areas

生物化學
分子醫學
分子生物學
藥學科學
藥物發現
臨床生物化學
有機化學

UN SDG

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10.1016/j.bmcl.2006.11.008

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title = "Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells",

abstract = "A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.",

keywords = "Cancer cells, Glucose, Paclitaxel, Targeted delivery",

author = "Liu, {Der Zen} and Supachok Sinchaikul and Reddy, {Peddiahgari Vasu Govardhana} and Chang, {Meng Yang} and Chen, {Shui Tein}",

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doi = "10.1016/j.bmcl.2006.11.008",

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AU - Liu, Der Zen

AU - Sinchaikul, Supachok

AU - Reddy, Peddiahgari Vasu Govardhana

AU - Chang, Meng Yang

AU - Chen, Shui Tein

PY - 2007/2/1

Y1 - 2007/2/1

N2 - A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.

AB - A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.

KW - Cancer cells

KW - Glucose

KW - Paclitaxel

KW - Targeted delivery

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M3 - Article

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SN - 0960-894X

VL - 17

SP - 617

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

摘要

ASJC Scopus subject areas

UN SDG

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