摘要
Acetylcholine release enhancers may have therapeutic value in the treatment of Alzheimer's disease. A series of 1,4-dihydro-4,4-bis(pyridinylmethyl)-2H-isoquinolin-3-ones (2-13) was synthesized as analogs of the known acetylcholine-release enhancer linopirdine (1). Their cholinergic activity was measured as the enhancement of indirectly-elicited twitch tension of the mouse diaphragm. Among the target compounds, 2-phenyl-4,4-bis(4-pyridinylmethyl)-4H-isoquinoline-1,3-dione (2) and 7-bromo-1,4-dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)-2H-isoquinolin-3-one (11) were found to be more potent than 1.
原文 | 英語 |
---|---|
頁(從 - 到) | 271-281 |
頁數 | 11 |
期刊 | Chinese Pharmaceutical Journal |
卷 | 54 |
發行號 | 4 |
出版狀態 | 已發佈 - 8月 2002 |
Keywords
- Acetylcholine release enhancers
- Alzheimer's disease
- Linopirdine
ASJC Scopus subject areas
- 藥理
- 藥學科學