TY - JOUR
T1 - SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH VARIOUS CHAIN LENGTHS
AU - Yeung, Hin‐Wing ‐W
AU - Yamashiro, Donald
AU - Chang, Wen‐Chang ‐C
AU - Li, Choh Hao
PY - 1978/1/1
Y1 - 1978/1/1
N2 - The synthesis of βh‐endorphin* ‐(1–15), ‐(1–21), ‐(1–26), ‐(1–28) and ‐(1–29) have been accomplished by the solid‐phase method. The opiate activities of the peptides were measured in the guinea pig ileum assay. Their relative potencies were βh‐endorphin (βh‐EP), 1.00; Met‐enkephalin, 0.25; βh‐EP‐(1–15), 0.17; βh‐EP‐(1–21), 0.46; βh‐EP‐(1–26), 0.48; βh‐EP‐(1–28), 0.89; βh‐EP‐(1–29), 1.04.
AB - The synthesis of βh‐endorphin* ‐(1–15), ‐(1–21), ‐(1–26), ‐(1–28) and ‐(1–29) have been accomplished by the solid‐phase method. The opiate activities of the peptides were measured in the guinea pig ileum assay. Their relative potencies were βh‐endorphin (βh‐EP), 1.00; Met‐enkephalin, 0.25; βh‐EP‐(1–15), 0.17; βh‐EP‐(1–21), 0.46; βh‐EP‐(1–26), 0.48; βh‐EP‐(1–28), 0.89; βh‐EP‐(1–29), 1.04.
KW - guinea pig ileum
KW - solid phase synthesis
KW - β‐endorphin
KW - β‐lipotropin
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U2 - 10.1111/j.1399-3011.1978.tb02866.x
DO - 10.1111/j.1399-3011.1978.tb02866.x
M3 - Article
C2 - 681084
AN - SCOPUS:0018188443
SN - 0367-8377
VL - 12
SP - 42
EP - 46
JO - International Journal of Peptide and Protein Research
JF - International Journal of Peptide and Protein Research
IS - 1
ER -