TY - JOUR
T1 - Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives
AU - Chin, Yi Ping
AU - Huang, Wei Jan
AU - Hsu, Feng-Lin
AU - Lin, Mei Hsiang
AU - Lin, Yuh Ling
PY - 2011/6
Y1 - 2011/6
N2 - This study examines the synthesis and antibacterial activities of 5,7-dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their antibacterial activities against five microbial species such as E. coli, S. aureus, K. pneumonia, P. aeruginosa, and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus aureus with a MIC value of 2.5 μg/mL for each of the compounds.
AB - This study examines the synthesis and antibacterial activities of 5,7-dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their antibacterial activities against five microbial species such as E. coli, S. aureus, K. pneumonia, P. aeruginosa, and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus aureus with a MIC value of 2.5 μg/mL for each of the compounds.
KW - 5,7-Dihydroxycoumarin
KW - Antibacterial activity
KW - Methicillin-resistance
KW - Serratin
UR - http://www.scopus.com/inward/record.url?scp=79958188913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958188913&partnerID=8YFLogxK
U2 - 10.1002/ardp.201000233
DO - 10.1002/ardp.201000233
M3 - Article
C2 - 21433055
AN - SCOPUS:79958188913
SN - 0365-6233
VL - 344
SP - 386
EP - 393
JO - Archiv der Pharmazie
JF - Archiv der Pharmazie
IS - 6
ER -