Synthesis and characterization of positive-charge functionalized mesoporous silica nanoparticles for oral drug delivery of an anti-inflammatory drug

Chia Hung Lee, Leu Wei Lo, Chung Yuan Mou, Chung Shi Yang

研究成果: 雜誌貢獻文章同行評審

197 引文 斯高帕斯(Scopus)

摘要

We synthesized mesoporous silica nanoparticles (MSN) with different densities of surface positive charges. The positive surface charge was generated by incorporating trimethylammonium (TA) functional groups into the framework of MSN (MSN-TA) via direct co-condensation of a TA-silane and tetraethoxysilane (TEOS) in the presence of a base as a catalyst. These MSN-TA samples have well-defined hexagonal structures with an average particle diameter of 100 nm, pore size of 2.7 nm, and surface area of about 1000 m2g-1. Anionic drug molecules, Orange II (a fluorescent tracing molecule), and sulfasalazine (an anti-inflammatory prodrug used for bowel disease), were effectively loaded into these MSN-TA samples and remained inside of the MSNTA under acidic environment (pH 2-5). The amounts of loading of both Orange II and sulfasalazine were increased with increasing positive charge densities resulting from the increasing number of TA groups. When these drug-loaded MSN-TA nanoparticles were placed in physiological buffer solution (pH 7.4), a partial negative surface charge on the MSN-TA was generated due to the deprotonation of silanol groups, and the strong electrostatic repulsion triggered a sustained release of the loaded molecules. MSN-TA as a nanovehicle for pH-dependent loading and controllable release of anionic drug molecules can be used as an oral delivery drug systems targeting at intestine. These drugs can be remained trapped in the nanovehicle when passing through the stomach's acidic environment and be released in intestine where the environmental pH is close to neutral.

原文英語
頁(從 - 到)3283-3292
頁數10
期刊Advanced Functional Materials
18
發行號20
DOIs
出版狀態已發佈 - 10月 23 2008
對外發佈

ASJC Scopus subject areas

  • 一般化學
  • 一般材料科學
  • 凝聚態物理學

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