摘要
A series of C6-substituted N-hydroxy-2-quinolineacrylamides (3–15), with four types of bridging groups have been synthesized. Most of these compounds exhibit antiproliferative activity against A549 and HCT116 cells and Western blot analysis revealed that they are able to inhibit HDAC. Measurement of the HDAC isoform activity of ether-containing compounds showed that compound 9 has distinct HDAC6 selectivity, more than 300-fold over other isoforms. This paper describes the development of 6-aryloxy-N-hydroxy-2-quinolineacrylamides as potential HDAC6 inhibitors.
原文 | 英語 |
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文章編號 | 115250 |
頁(從 - 到) | 115250 |
期刊 | Bioorganic and Medicinal Chemistry |
卷 | 28 |
發行號 | 3 |
DOIs | |
出版狀態 | 已發佈 - 2月 1 2020 |
ASJC Scopus subject areas
- 生物化學
- 分子醫學
- 分子生物學
- 藥學科學
- 藥物發現
- 臨床生物化學
- 有機化學