SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

JAMES BLAKE; WEN‐CHANG ‐C CHANG; CHOH HAO LI

doi:10.1111/j.1399-3011.1979.tb01933.x

SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

JAMES BLAKE, WEN‐CHANG ‐C CHANG, CHOH HAO LI

研究成果: 雜誌貢獻 › 文章 › 同行評審

6 引文斯高帕斯（Scopus）

摘要

Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.

原文	英語
頁（從 - 到）	275-280
頁數	6
期刊	International Journal of Peptide and Protein Research
卷	14
發行號	3
DOIs	https://doi.org/10.1111/j.1399-3011.1979.tb01933.x
出版狀態	已發佈 - 1月 1 1979
對外發佈	是

ASJC Scopus subject areas

生物化學

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10.1111/j.1399-3011.1979.tb01933.x

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abstract = "Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.",

keywords = "disulfide bridges, opiate activity, radioimmunoactivity, β‐endorphin",

author = "JAMES BLAKE and CHANG, {WEN‐CHANG ‐C} and LI, {CHOH HAO}",

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PY - 1979/1/1

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N2 - Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.

AB - Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.

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KW - radioimmunoactivity

KW - β‐endorphin

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SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

摘要

ASJC Scopus subject areas

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