Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang; Shwu Jiuan Lin; Tsang Hsiung Yang; Kuo Hsiung Lee

doi:10.1016/0960-894X(96)00158-8

Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang, Shwu Jiuan Lin, Tsang Hsiung Yang, Kuo Hsiung Lee

研究成果: 雜誌貢獻 › 文章 › 同行評審

40 引文斯高帕斯（Scopus）

摘要

Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

原文	英語
頁（從 - 到）	941-944
頁數	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	6
發行號	8
DOIs	https://doi.org/10.1016/0960-894X(96)00158-8
出版狀態	已發佈 - 4月 23 1996

ASJC Scopus subject areas

藥物發現
分子醫學
分子生物學
生物化學
臨床生物化學
藥學科學
有機化學

UN SDG

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10.1016/0960-894X(96)00158-8

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abstract = "Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.",

author = "Yang, {Li Ming} and Lin, {Shwu Jiuan} and Yang, {Tsang Hsiung} and Lee, {Kuo Hsiung}",

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AU - Lin, Shwu Jiuan

AU - Yang, Tsang Hsiung

AU - Lee, Kuo Hsiung

PY - 1996/4/23

Y1 - 1996/4/23

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AB - Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

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Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

摘要

ASJC Scopus subject areas

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