摘要
3-Substituted 4-arylpyridines (5a-i) were synthesized in good yields by reaction of mixed copper, zinc aryl organometallics (2a-e) with 1-ethoxycarbonyl-pyridinium chlorides (1a-d) followed by o-chloranil oxidation under reflux in toluene. The 4-arylpyridines (5a-i) are obtained predominantly. Having compounds (5a-i) in hand, a convenient method was developed for the synthesis of 2-azafluorenones (7a-f) by using cyclization of 4-arylpyridines (5a-i) with polyphosphoric acid.
原文 | 英語 |
---|---|
頁(從 - 到) | 507-518 |
頁數 | 12 |
期刊 | Heterocycles |
卷 | 36 |
發行號 | 3 |
DOIs | |
出版狀態 | 已發佈 - 3月 1 1993 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 分析化學
- 藥理
- 有機化學