Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

Po Wei Tsai; Cheng Yang Hsieh; Jasmine U. Ting; Yi Ru Ciou; Chia Jung Lee; Chieh Lun Hsieh; Tzu Kuan Lien; Chung Chuan Hsueh; Bor Yann Chen

doi:10.1016/j.jtice.2022.104365

Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

Po Wei Tsai, Cheng Yang Hsieh, Jasmine U. Ting, Yi Ru Ciou, Chia Jung Lee, Chieh Lun Hsieh, Tzu Kuan Lien, Chung Chuan Hsueh, Bor Yann Chen

研究成果: 雜誌貢獻 › 文章 › 同行評審

16 引文斯高帕斯（Scopus）

摘要

Background: Traditional Chinese medicine (TCM) has been used as an "immune booster” for disease prevention and clinical treatment since ancient China. However, many studies were focused on the organic herbal extract rather than aqueous herbal extract (AHE; decoction). Due to the COVID-19 pandemics, this study tended to decipher phytochemical contents in the decoction of herbs and derived bioactivities (e.g., anti-oxidant and anti-inflammatory properties). As prior works revealed, the efficacy of Parkinson's medicines and antiviral flavonoid herbs was strongly governed by their bioenergy-stimulating proficiency. Methods: Herbal extracts were prepared by using a traditional Chinese decoction pot. After filtration and evaporation, crude extracts were used to prepare sample solutions for various bioassays. The phytochemical content and bioactivities of AHEs were determined via ELISA microplate reader. Microbial fuel cells (MFCs) were used as a novel platform to evaluate bioenergy contents with electron-transfer characteristics for antiviral drug development. Significant findings: Regarding 18 TCM herbal extracts for the prevention of SARS and H1N1 influenza, comparison on total polyphenol, flavonoid, condensed tannins and polysaccharides were conducted. Moreover, considerable total flavonoid contents were detected for 11 herb extracts. These AEHs were not only rich in phytonutrient contents but also plentiful in anti-oxidant and anti-inflammatory activities. Herbs with high polyphenol content had higher antioxidant activity. Forsythia suspensa extract expressed the highest inhibition against nitric oxide production for anti-inflammation. MFC bioenergy-stimulating studies also revealed that top ranking COVID-19 efficacious herbs were both bioenergy driven and electron mediated. That is, electron transfer-controlled bioenergy extraction was significant to antiviral characteristics for anti-COVID-19 drug development.

原文	英語
文章編號	104365
期刊	Journal of the Taiwan Institute of Chemical Engineers
卷	135
DOIs	https://doi.org/10.1016/j.jtice.2022.104365
出版狀態	已發佈 - 6月 2022

ASJC Scopus subject areas

一般化學
一般化學工程

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10.1016/j.jtice.2022.104365

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Link to publication in Scopus

引用此

Tsai, P. W., Hsieh, C. Y., Ting, J. U., Ciou, Y. R., Lee, C. J., Hsieh, C. L., Lien, T. K., Hsueh, C. C., & Chen, B. Y. (2022). Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development. Journal of the Taiwan Institute of Chemical Engineers, 135, 文章 104365. https://doi.org/10.1016/j.jtice.2022.104365

Tsai, PW, Hsieh, CY, Ting, JU, Ciou, YR, Lee, CJ, Hsieh, CL, Lien, TK, Hsueh, CC & Chen, BY 2022, 'Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development', Journal of the Taiwan Institute of Chemical Engineers, 卷 135, 104365. https://doi.org/10.1016/j.jtice.2022.104365

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title = "Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development",

abstract = "Background: Traditional Chinese medicine (TCM) has been used as an {"}immune booster” for disease prevention and clinical treatment since ancient China. However, many studies were focused on the organic herbal extract rather than aqueous herbal extract (AHE; decoction). Due to the COVID-19 pandemics, this study tended to decipher phytochemical contents in the decoction of herbs and derived bioactivities (e.g., anti-oxidant and anti-inflammatory properties). As prior works revealed, the efficacy of Parkinson's medicines and antiviral flavonoid herbs was strongly governed by their bioenergy-stimulating proficiency. Methods: Herbal extracts were prepared by using a traditional Chinese decoction pot. After filtration and evaporation, crude extracts were used to prepare sample solutions for various bioassays. The phytochemical content and bioactivities of AHEs were determined via ELISA microplate reader. Microbial fuel cells (MFCs) were used as a novel platform to evaluate bioenergy contents with electron-transfer characteristics for antiviral drug development. Significant findings: Regarding 18 TCM herbal extracts for the prevention of SARS and H1N1 influenza, comparison on total polyphenol, flavonoid, condensed tannins and polysaccharides were conducted. Moreover, considerable total flavonoid contents were detected for 11 herb extracts. These AEHs were not only rich in phytonutrient contents but also plentiful in anti-oxidant and anti-inflammatory activities. Herbs with high polyphenol content had higher antioxidant activity. Forsythia suspensa extract expressed the highest inhibition against nitric oxide production for anti-inflammation. MFC bioenergy-stimulating studies also revealed that top ranking COVID-19 efficacious herbs were both bioenergy driven and electron mediated. That is, electron transfer-controlled bioenergy extraction was significant to antiviral characteristics for anti-COVID-19 drug development.",

keywords = "Bioenergy extraction, COVID-19, Electron transfer, Forsythia suspensa, Microbial fuel cells, Traditional Chinese medicine",

author = "Tsai, {Po Wei} and Hsieh, {Cheng Yang} and Ting, {Jasmine U.} and Ciou, {Yi Ru} and Lee, {Chia Jung} and Hsieh, {Chieh Lun} and Lien, {Tzu Kuan} and Hsueh, {Chung Chuan} and Chen, {Bor Yann}",

note = "Funding Information: The authors sincerely appreciate financial supports ( MOST 109-2221-E-197-016-MY3 , 110-2221-E-197-008 ) from the Taiwan's Ministry of Science and Technology and are very thankful to Office of Research and Development, Chang Jung Christian University, for funding this study. The authors also sincerely thank anonymous reviewers for their comments of great significance for this study. Publisher Copyright: {\textcopyright} 2022 Taiwan Institute of Chemical Engineers",

year = "2022",

month = jun,

doi = "10.1016/j.jtice.2022.104365",

language = "English",

volume = "135",

journal = "Journal of the Taiwan Institute of Chemical Engineers",

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publisher = "Taiwan Institute of Chemical Engineers",

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T1 - Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

AU - Tsai, Po Wei

AU - Hsieh, Cheng Yang

AU - Ting, Jasmine U.

AU - Ciou, Yi Ru

AU - Lee, Chia Jung

AU - Hsieh, Chieh Lun

AU - Lien, Tzu Kuan

AU - Hsueh, Chung Chuan

AU - Chen, Bor Yann

N1 - Funding Information: The authors sincerely appreciate financial supports ( MOST 109-2221-E-197-016-MY3 , 110-2221-E-197-008 ) from the Taiwan's Ministry of Science and Technology and are very thankful to Office of Research and Development, Chang Jung Christian University, for funding this study. The authors also sincerely thank anonymous reviewers for their comments of great significance for this study. Publisher Copyright: © 2022 Taiwan Institute of Chemical Engineers

PY - 2022/6

Y1 - 2022/6

N2 - Background: Traditional Chinese medicine (TCM) has been used as an "immune booster” for disease prevention and clinical treatment since ancient China. However, many studies were focused on the organic herbal extract rather than aqueous herbal extract (AHE; decoction). Due to the COVID-19 pandemics, this study tended to decipher phytochemical contents in the decoction of herbs and derived bioactivities (e.g., anti-oxidant and anti-inflammatory properties). As prior works revealed, the efficacy of Parkinson's medicines and antiviral flavonoid herbs was strongly governed by their bioenergy-stimulating proficiency. Methods: Herbal extracts were prepared by using a traditional Chinese decoction pot. After filtration and evaporation, crude extracts were used to prepare sample solutions for various bioassays. The phytochemical content and bioactivities of AHEs were determined via ELISA microplate reader. Microbial fuel cells (MFCs) were used as a novel platform to evaluate bioenergy contents with electron-transfer characteristics for antiviral drug development. Significant findings: Regarding 18 TCM herbal extracts for the prevention of SARS and H1N1 influenza, comparison on total polyphenol, flavonoid, condensed tannins and polysaccharides were conducted. Moreover, considerable total flavonoid contents were detected for 11 herb extracts. These AEHs were not only rich in phytonutrient contents but also plentiful in anti-oxidant and anti-inflammatory activities. Herbs with high polyphenol content had higher antioxidant activity. Forsythia suspensa extract expressed the highest inhibition against nitric oxide production for anti-inflammation. MFC bioenergy-stimulating studies also revealed that top ranking COVID-19 efficacious herbs were both bioenergy driven and electron mediated. That is, electron transfer-controlled bioenergy extraction was significant to antiviral characteristics for anti-COVID-19 drug development.

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Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development

摘要

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