Swedish two-county trial: Impact of mammographic screening on breast cancer mortality during 3 decades

László Tabár, Bedrich Vitak, Tony Hsiu Hsi Chen, Amy Ming Fang Yen, Anders Cohen, Tibor Tot, Sherry Yueh Hsia Chiu, Sam Li Sheng Chen, Jean Ching Yuan Fann, Johan Rosell, Helena Fohlin, Robert A. Smith, Stephen W. Duffy

研究成果: 雜誌貢獻文章同行評審

581 引文 斯高帕斯(Scopus)


Purpose: To estimate the long-term (29-year) Effect of mammographic screening on breast cancer mortality in terms of both relative and absolute effects. Materials and Methods: This study was carried out under the auspices of the Swedish National Board of Health and Welfare. The board determined that, because randomization was at a community level and was to invitation to screening, informed verbal consent could be given by the participants when they attended the screening examination. A total of 133 065 women aged 40-74 years residing in two Swedish counties were randomized into a group invited to mammographic screening and a control group receiving usual care. Case status and cause of death were determined by the local trial end point committees and, independently, by an external committee. Mortality analysis was performed by using negative binomial regression. Results: There was a highly significant reduction in breast cancer mortality in women invited to screening according to both local end point committee data (relative risk [RR] = 0.69; 95% confidence interval: 0.56, 0.84; P <.0001) and consensus data (RR = 0.73; 95% confidence interval: 0.59, 0.89; P =.002). At 29 years of follow-up, the number of women needed to undergo screening for 7 years to prevent one breast cancer death was 414 according to local data and 519 according to consensus data. Most prevented breast cancer deaths would have occurred (in the absence of screening) after the first 10 years of follow-up. Conclusion: Invitation to mammographic screening results in a highly significant decrease in breast cancer-specific mortality. Evaluation of the full impact of screening, in particular estimates of absolute benefit and number needed to screen, requires follow-up times exceeding 20 years because the observed number of breast cancer deaths prevented increases with increasing time of follow-up.
頁(從 - 到)658-663
出版狀態已發佈 - 9月 2011

ASJC Scopus subject areas

  • 放射學、核子醫學和影像學


深入研究「Swedish two-county trial: Impact of mammographic screening on breast cancer mortality during 3 decades」主題。共同形成了獨特的指紋。