Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension

Yung Hsin Cheng, Kuo Hsuan Hung, Tung Hu Tsai, Chia Jung Lee, Ruy Yu Ku, Allen Wen Hsiang Chiu, Shih Hwa Chiou, Catherine Jui Ling Liu

研究成果: 雜誌貢獻文章同行評審

101 引文 斯高帕斯(Scopus)

摘要

Glaucoma is an irreversible ocular disease that may lead to progressive visual field loss and eventually to blindness with inadequately controlled intraocular pressure (IOP). Latanoprost is one of the most potent ocular hypotensive compounds, the current first-line therapy in glaucoma. However, the daily instillation required for efficacy and undesirable side-effects are major causes of treatment adherence failure and persistence in glaucoma therapy. In the present study, we developed an injectable thermosensitive chitosan/gelatin/glycerol phosphate (C/G/GP) hydrogel as a sustained-release system of latanoprost for glaucoma treatment. The latanoprost-loaded C/G/GP hydrogel can gel within 1 min at 37 °C. The results show a sustained release of latanoprost from C/G/GP hydrogel in vitro and in vivo. The latanoprost-loaded C/G/GP hydrogel showed a good in vitro and in vivo biocompatibility. A rabbit model of glaucoma was established by intravitreal injection of triamcinolone acetonide. After a single subconjunctival injection of latanoprost-loaded C/G/GP hydrogel, IOP was significantly decreased within 8 days and then remained at a normal level. The results of the study suggest that latanoprost-loaded C/G/GP hydrogel may have a potential application in glaucoma therapy.

原文英語
頁(從 - 到)4360-4366
頁數7
期刊Acta Biomaterialia
10
發行號10
DOIs
出版狀態已發佈 - 10月 1 2014
對外發佈

ASJC Scopus subject areas

  • 生物技術
  • 生物材料
  • 生物化學
  • 生物醫學工程
  • 分子生物學

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