Survival benefit of tamoxifen in estrogen receptor-negative and progesterone receptor-positive low grade breast cancer patients

Li Heng Yang, Hsin Shun Tseng, Che Lin, Li Sheng Chen, Shou Tung Chen, Shou Jen Kuo, Dar Ren Chen

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40 引文 斯高帕斯(Scopus)

摘要

Purpose: This study aimed to analyze the efficacy and prognostic significance of adjuvant tamoxifen in breast cancer patients with various hormone receptor statuses. Methods: Typically, 1,260 female breast cancer patients were recruited in this study. The correlation between estrogen receptor (ER)/progesterone receptor (PR) phenotypes and clinical characteristics was investigated, and the survival rate was assessed after 5-year follow-up. Results: The 5-year overall survival (85%) was better in women under the age of 50 years. Patients with ER+/PR+ tumors had a better 5-year survival rate (94%); those with ER-/PRtumors experienced the worst outcome (74% survival rate); whereas singlepositive cases were in between. In 97 out of 128 patients with ER-/PR+ tumors, tamoxifen was given as adjuvant hormonal therapy, and it increased the survival benefit in the lower grade group in terms of overall survival and disease-free survival (p= 0.01 and p=0.03, respectively). Conclusion: For high-grade tumors with ER-/PR+, adjuvant tamoxifen therapy may have no survival benefit, whereas for the patients with low-grade ER-/ PR+ tumors, adjuvant tamoxifen therapy is highly suggestive.
原文英語
頁(從 - 到)288-295
頁數8
期刊Journal of Breast Cancer
15
發行號3
DOIs
出版狀態已發佈 - 9月 2012

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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