Surface nanotopography of an anodized Ti-6Al-7Nb alloy enhances cell growth

Her Hsiung Huang, Chia Ping Wu, Ying Sui Sun, Wei En Yang, Tzu Hsin Lee

研究成果: 雜誌貢獻文章同行評審

26 引文 斯高帕斯(Scopus)


The α/β-type Ti-6Al-7Nb alloy is a potential replacement for α/β-type Ti-6Al-4V alloy, which is widely used in biomedical implant applications. The biological response to implant material is dependent on the surface characteristics of the material. In the present study, a simple and fast process was developed to perform an electrochemical anodization treatment on Ti-6Al-7Nb alloy. The proposed process yielded a thin surface nanotopography, which enhanced cell growth on the Ti-6Al-7Nb alloy. The surface characteristics, including the morphology, wettability, and protein adsorption, were investigated, and the cytotoxicity was evaluated according to International Organization for Standardization 10993-5 specifications. Cell adhesion of human bone marrow mesenchymal stem cells on the test specimens was observed via fluorescence microscopy and scanning electron microscopy. The anodization process produced a surface nanotopography (pore size <100 nm) on anodized Ti-6Al-7Nb alloy, which enhanced the wettability, protein adsorption, cell adhesion, cell migration, and cell mineralization. The results showed that the surface nanotopography produced using the proposed electrochemical anodization process enhanced cell growth on anodized Ti-6Al-7Nb alloy for implant applications.
頁(從 - 到)S648-S654
期刊Journal of Alloys and Compounds
出版狀態已發佈 - 12月 5 2014

ASJC Scopus subject areas

  • 材料力學
  • 機械工業
  • 金屬和合金
  • 材料化學


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