TY - JOUR
T1 - Surface nanoporosity of β-type Ti-25Nb-25Zr alloy for the enhancement of protein adsorption and cell response
AU - Huang, Her Hsiung
AU - Wu, Chia Ping
AU - Sun, Ying Sui
AU - Yang, Wei En
AU - Lin, Mau Chin
AU - Lee, Tzu Hsin
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - This paper outlines a simple method for the electrochemical anodization of β-type Ti-25Nb-25Zr (Ti25Nb25Zr) alloy with a low elastic modulus (approximately 70. GPa) to alter its surface topography for bone implant applications. Surface characteristics including topography, roughness, hydrophilicity, and protein adsorption (fibronectin and albumin) were investigated. Human bone marrow mesenchymal stem cell responses, including adhesion, migration, proliferation, and mineralization, were also evaluated. The experimental results demonstrate that the electrochemical anodization process produced a nanoporous surface (pore size <. 15. nm) on Ti25Nb25Zr alloy. This surface nanotopography did not alter the surface roughness or hydrophilicity of the Ti25Nb25Zr alloy but was capable of enhancing biological responses, including protein adsorption, cell adhesion, cell migration, cell proliferation, and cell mineralization. The created surface nanoporosity on β-type Ti25Nb25Zr alloy has a high potential for bone implant applications.
AB - This paper outlines a simple method for the electrochemical anodization of β-type Ti-25Nb-25Zr (Ti25Nb25Zr) alloy with a low elastic modulus (approximately 70. GPa) to alter its surface topography for bone implant applications. Surface characteristics including topography, roughness, hydrophilicity, and protein adsorption (fibronectin and albumin) were investigated. Human bone marrow mesenchymal stem cell responses, including adhesion, migration, proliferation, and mineralization, were also evaluated. The experimental results demonstrate that the electrochemical anodization process produced a nanoporous surface (pore size <. 15. nm) on Ti25Nb25Zr alloy. This surface nanotopography did not alter the surface roughness or hydrophilicity of the Ti25Nb25Zr alloy but was capable of enhancing biological responses, including protein adsorption, cell adhesion, cell migration, cell proliferation, and cell mineralization. The created surface nanoporosity on β-type Ti25Nb25Zr alloy has a high potential for bone implant applications.
KW - Cell response
KW - Electrochemical anodization
KW - Protein adsorption
KW - Surface nanoporosity
KW - Ti-25Nb-25Zr alloy
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U2 - 10.1016/j.surfcoat.2014.02.037
DO - 10.1016/j.surfcoat.2014.02.037
M3 - Article
AN - SCOPUS:84923422735
SN - 0257-8972
VL - 259
SP - 206
EP - 212
JO - Surface and Coatings Technology
JF - Surface and Coatings Technology
IS - PB
ER -