SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying; Shin Tang Su; Pang Hung Hsu; Che Chang Chang; I. Ying Lin; Yu Hsuan Tseng; Ming Daw Tsai; Hsiu Ming Shih; Kuo I. Lin

doi:10.1038/embor.2012.60

SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying
, Shin Tang Su
, Pang Hung Hsu
, Che Chang Chang
, I. Ying Lin
, Yu Hsuan Tseng
, Ming Daw Tsai
, Hsiu Ming Shih
, Kuo I. Lin

研究成果: 雜誌貢獻 › 文章 › 同行評審

21 引文斯高帕斯（Scopus）

摘要

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

原文	英語
頁（從 - 到）	631-637
頁數	7
期刊	EMBO Reports
卷	13
發行號	7
DOIs	https://doi.org/10.1038/embor.2012.60
出版狀態	已發佈 - 7月 2012
對外發佈	是

ASJC Scopus subject areas

生物化學
分子生物學
遺傳學

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10.1038/embor.2012.60

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AU - Tseng, Yu Hsuan

AU - Tsai, Ming Daw

AU - Shih, Hsiu Ming

AU - Lin, Kuo I.

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KW - SUMO

KW - differentiation

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SUMOylation of Blimp-1 is critical for plasma cell differentiation

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