SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying; Shin Tang Su; Pang Hung Hsu; Che Chang Chang; I. Ying Lin; Yu Hsuan Tseng; Ming Daw Tsai; Hsiu Ming Shih; Kuo I. Lin

doi:10.1038/embor.2012.60

SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying, Shin Tang Su, Pang Hung Hsu, Che Chang Chang, I. Ying Lin, Yu Hsuan Tseng, Ming Daw Tsai, Hsiu Ming Shih, Kuo I. Lin

研究成果: 雜誌貢獻 › 文章 › 同行評審

18 引文斯高帕斯（Scopus）

摘要

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

原文	英語
頁（從 - 到）	631-637
頁數	7
期刊	EMBO Reports
卷	13
發行號	7
DOIs	https://doi.org/10.1038/embor.2012.60
出版狀態	已發佈 - 7月 2012
對外發佈	是

ASJC Scopus subject areas

生物化學
分子生物學
遺傳學

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10.1038/embor.2012.60

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AU - Tseng, Yu Hsuan

AU - Tsai, Ming Daw

AU - Shih, Hsiu Ming

AU - Lin, Kuo I.

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SUMOylation of Blimp-1 is critical for plasma cell differentiation

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