@article{61b342dd2f7f469f9797f14e7704e727,
title = "SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation",
abstract = "Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 inthe regulation of STAT5 activation during early lymphoid development.",
author = "{Van Nguyen}, Thang and Pornpimon Angkasekwinai and Hong Dou and Lin, {Feng Ming} and Lu, {Long Sheng} and Jinke Cheng and Chin, {Y. Eugene} and Chen Dong and Yeh, {Edward T H}",
note = "Funding Information: We would like to thank Drs. L.-Y. Yu-Lee, Fang Liu, Koichi Ikuta, Yong-Jun Liu, and Stephanie S. Watowich for plasmids; Dr. J.C. Z{\'u}{\~n}iga-Pfl{\"u}cker for OP9-GFP and OP9-DL1 cells; and Dr J.N. Ihle for STAT5-deficient MEF cells. We would also thank Drs. Shao-Cong Sun, Phillip Carpenter, Sue-Hwa Lin, and Jingxiong Wang for reading of the manuscript, and the flow cytometry core facility (Karen Martinez, David He, and Amy Cortez) of MD Anderson Cancer Center for technical assistance. This work was supported in part by a National Institute of Health Grant to E.T.H.Y (CA239520). T.V.N receives a fellowship from Vietnam Education Foundation. E.T.H.Y. is the McNair Scholar of the Texas Heart Institute/St. Luke's Episcopal Hospital. The authors declare no conflicting financial interests. ",
year = "2012",
month = jan,
day = "27",
doi = "10.1016/j.molcel.2011.12.026",
language = "English",
volume = "45",
pages = "210--221",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "2",
}