TY - JOUR
T1 - Studies on antiulcer Chinese herbs (1)
AU - Lin, Ming Hsuan
AU - Hsu, Shih Yuan
AU - Sheih, Ming Jer
AU - Chen, Tzeng Fu
AU - Chen, Chau Yang
PY - 1998/2
Y1 - 1998/2
N2 - We systematically investigated the effects of five Chinese herbal drugs (Atractylodes macrocephala Koidz, Paeonia lactiflora Pall., Citrus aurantium L., Alpinia officinarum Hance and Magnolia officinalis Rehd. et Wils.) available in Taiwan on experimental gastric ulcers. Crude water extracts were tested against five experimental acute ulcers (stress ulcers, Shay's ulcers, aspirin- induced gastric ulcers, mepirizole- induced duodenal lesions and cysteamine- induced duodenal lesions) and two experimental chronic ulcers (acetic acid- induced and thermocautery ulcers). Atractylodes macrocephala possessed significant protective effects against acute and chronic experimental ulcers in male Wistar rats. Alpinia officinarum and the other extracts also displayed statistically significant activities. These Chinese herbal drugs therefore possess antisecretory and anti-ulcer activities.
AB - We systematically investigated the effects of five Chinese herbal drugs (Atractylodes macrocephala Koidz, Paeonia lactiflora Pall., Citrus aurantium L., Alpinia officinarum Hance and Magnolia officinalis Rehd. et Wils.) available in Taiwan on experimental gastric ulcers. Crude water extracts were tested against five experimental acute ulcers (stress ulcers, Shay's ulcers, aspirin- induced gastric ulcers, mepirizole- induced duodenal lesions and cysteamine- induced duodenal lesions) and two experimental chronic ulcers (acetic acid- induced and thermocautery ulcers). Atractylodes macrocephala possessed significant protective effects against acute and chronic experimental ulcers in male Wistar rats. Alpinia officinarum and the other extracts also displayed statistically significant activities. These Chinese herbal drugs therefore possess antisecretory and anti-ulcer activities.
KW - Antiulcer agent
KW - Experimental gastric ulcers
KW - Ulcer protective effects
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M3 - Article
AN - SCOPUS:0031782559
SN - 1016-1015
VL - 50
SP - 55
EP - 66
JO - Taiwan Pharmaceutical Journal
JF - Taiwan Pharmaceutical Journal
IS - 1
ER -