Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsing Pang Hsieh; Jing Ping Liou; Ying Ting Lin; Neeraj Mahindroo; Jang Yang Chang; Yung Ning Yang; Shuenn Shing Chern; Uan Kang Tan; Chun Wei Chang; Tung Wei Chen; Chi Hung Lin; Ying Ying Chang; Chiung Chiu Wang

doi:10.1016/S0960-894X(02)00850-8

Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsing Pang Hsieh
, Jing Ping Liou
, Ying Ting Lin
, Neeraj Mahindroo
, Jang Yang Chang
, Yung Ning Yang
, Shuenn Shing Chern
, Uan Kang Tan
, Chun Wei Chang
, Tung Wei Chen
, Chi Hung Lin
, Ying Ying Chang
, Chiung Chiu Wang

研究成果: 雜誌貢獻 › 文章 › 同行評審

83 引文斯高帕斯（Scopus）

摘要

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

原文	英語
頁（從 - 到）	101-105
頁數	5
期刊	Bioorganic and Medicinal Chemistry Letters
卷	13
發行號	1
DOIs	https://doi.org/10.1016/S0960-894X(02)00850-8
出版狀態	已發佈 - 1月 6 2003
對外發佈	是

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 良好的健康和福祉

ASJC Scopus subject areas

生物化學
分子醫學
分子生物學
藥學科學
藥物發現
臨床生物化學
有機化學

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10.1016/S0960-894X(02)00850-8

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Hsieh, H. P., Liou, J. P., Lin, Y. T., Mahindroo, N., Chang, J. Y., Yang, Y. N., Chern, S. S., Tan, U. K., Chang, C. W., Chen, T. W., Lin, C. H., Chang, Y. Y., & Wang, C. C. (2003). Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents. Bioorganic and Medicinal Chemistry Letters, 13(1), 101-105. https://doi.org/10.1016/S0960-894X(02)00850-8

Hsieh, HP, Liou, JP, Lin, YT, Mahindroo, N, Chang, JY, Yang, YN, Chern, SS, Tan, UK, Chang, CW, Chen, TW, Lin, CH, Chang, YY & Wang, CC 2003, 'Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents', Bioorganic and Medicinal Chemistry Letters, 卷 13, 編號 1, 頁 101-105. https://doi.org/10.1016/S0960-894X(02)00850-8

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title = "Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents",

abstract = "Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.",

author = "Hsieh, \{Hsing Pang\} and Liou, \{Jing Ping\} and Lin, \{Ying Ting\} and Neeraj Mahindroo and Chang, \{Jang Yang\} and Yang, \{Yung Ning\} and Chern, \{Shuenn Shing\} and Tan, \{Uan Kang\} and Chang, \{Chun Wei\} and Chen, \{Tung Wei\} and Lin, \{Chi Hung\} and Chang, \{Ying Ying\} and Wang, \{Chiung Chiu\}",

note = "Funding Information: This work was financially supported by National Health Research Institutes, Taiwan, Republic of China. The authors are grateful to Ms. Edith Hsiao-Wen Chu and Ms. Shiau-Fen Jung for their administrative supports. ",

year = "2003",

month = jan,

day = "6",

doi = "10.1016/S0960-894X(02)00850-8",

language = "English",

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T1 - Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

AU - Hsieh, Hsing Pang

AU - Liou, Jing Ping

AU - Lin, Ying Ting

AU - Mahindroo, Neeraj

AU - Chang, Jang Yang

AU - Yang, Yung Ning

AU - Chern, Shuenn Shing

AU - Tan, Uan Kang

AU - Chang, Chun Wei

AU - Chen, Tung Wei

AU - Lin, Chi Hung

AU - Chang, Ying Ying

AU - Wang, Chiung Chiu

N1 - Funding Information: This work was financially supported by National Health Research Institutes, Taiwan, Republic of China. The authors are grateful to Ms. Edith Hsiao-Wen Chu and Ms. Shiau-Fen Jung for their administrative supports.

PY - 2003/1/6

Y1 - 2003/1/6

N2 - Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

AB - Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

UR - https://www.scopus.com/pages/publications/10744225059

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DO - 10.1016/S0960-894X(02)00850-8

M3 - Article

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AN - SCOPUS:10744225059

SN - 0960-894X

VL - 13

SP - 101

EP - 105

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

摘要

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ASJC Scopus subject areas

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