TY - JOUR
T1 - Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc
AU - Li, Jing
AU - Wang, Damao
AU - Xing, Xiaohui
AU - Cheng, Ting Jen Rachel
AU - Liang, Pi Hui
AU - Bulone, Vincent
AU - Park, Jeong Hill
AU - Hsieh, Yves S.Y.
N1 - Funding Information:
We thank the Knut and Alice Wallenberg Foundation , the Swedish Foundation for International Cooperation in Research and Higher Education (STINT) Korea-Sweden Research Cooperation (grants to Y. H.) and the ARC Centre of Excellence in Plant Cell Walls with matching funding from KTH (grants to V. B.) for supporting this work.
Publisher Copyright:
© 2019
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Ginseng marc is a major by-product of the ginseng industry currently used as animal feed or fertilizer. This fibrous, insoluble waste stream is rich in cell wall polysaccharides and therefore a potential source of ingredients for functional food with health-promoting properties. However, the extraction of these polysaccharides has proved problematic and their exact composition remains unknown. Here we have analysed the composition, structure and biological activity of polysaccharides from ginseng root, stem and leaf marc fractionated using a chelator and alkali solutions. The pectic fraction has been extracted from root marc in high abundance and can activate the production of interleukine-1α and the hematopoietic growth factor by RAW 264.7 murine macrophage cells, which are important immune regulators of T-cells during inflammatory responses and infection processes. Our study reveals the potential to increase the value of ginseng marc by generating carbohydrate-based products with a higher value than animal feed.
AB - Ginseng marc is a major by-product of the ginseng industry currently used as animal feed or fertilizer. This fibrous, insoluble waste stream is rich in cell wall polysaccharides and therefore a potential source of ingredients for functional food with health-promoting properties. However, the extraction of these polysaccharides has proved problematic and their exact composition remains unknown. Here we have analysed the composition, structure and biological activity of polysaccharides from ginseng root, stem and leaf marc fractionated using a chelator and alkali solutions. The pectic fraction has been extracted from root marc in high abundance and can activate the production of interleukine-1α and the hematopoietic growth factor by RAW 264.7 murine macrophage cells, which are important immune regulators of T-cells during inflammatory responses and infection processes. Our study reveals the potential to increase the value of ginseng marc by generating carbohydrate-based products with a higher value than animal feed.
KW - Cell wall polysaccharides
KW - Ginseng marc
KW - Murine macrophage cells
KW - Panax ginseng
KW - Structure
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U2 - 10.1016/j.ijbiomac.2019.05.077
DO - 10.1016/j.ijbiomac.2019.05.077
M3 - Article
C2 - 31121231
AN - SCOPUS:85066087024
SN - 0141-8130
VL - 135
SP - 29
EP - 37
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -
