TY - JOUR
T1 - Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly
AU - Le, Dao
AU - Wagner, Friederike
AU - Takamiya, Masanari
AU - Hsiao, I-Lun
AU - Gil Alvaradejo, Gabriela
AU - Strähle, Uwe
AU - Weiss, Carsten
AU - Delaittre, Guillaume
PY - 2019
Y1 - 2019
N2 - We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.
AB - We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.
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U2 - 10.1039/c9cc00407f
DO - 10.1039/c9cc00407f
M3 - Article
C2 - 30860243
SN - 1359-7345
VL - 55
SP - 3741
EP - 3744
JO - Chemical Communications
JF - Chemical Communications
IS - 26
ER -