@article{39bf913292b647f1ad32c482661b8117,
title = "Stimulatory effect of D-ephedrine on β3-adrenoceptors in adipose tissue of rats",
abstract = "The effect of ephedrine on β3-adrenoceptors (β3-AR) was studied in the isolated adipose tissue of Wistar rat. Incubation with D-ephedrine (0.1-10 μM) induced a concentration-dependent decrease of uptake of [14C]-deoxy-D-glucose into white adipose tissues (WAT). The inhibitory effect of D-ephedrine was potentiated by BRL 37344, the agonist of β3-AR and concentration-dependently inhibited by SR 59230A, the selective antagonist of β3-AR. The action of D-ephedrine on β3-AR was further blocked by the antibodies for β3-AR, but not the immunoglobulin, in a concentration-dependent manner. Moreover, D-ephedrine increased glycerol release from the isolated brown adipose tissues (BAT) and this action was also abolished by SR 59230A at concentration sufficient to block β3-AR. Thus, these results suggest that D-ephedrine has the ability to activate β3-AR both in WAT and BAT of Wistar rats in vitro.",
keywords = "BRL 37344, Brown adipose tissues, D-Ephedrine, Glucose uptake, Lipolysis, SR 59230A, White adipose tissues, β-Adrenoceptors",
author = "Cheng, {Juei Tang} and Liu, {I. Min} and Yen, {Shi Ting} and Juang, {Shiow Wen} and Liu, {Tsang Pai} and Paul Chan",
note = "Funding Information: We appreciate Dr. Luciano Manara (Sanofi Midy, Milan, Italy) for kindly supplying SR 59230A. Thanks are also due to Taiwan Green Cross (Taipei, Taiwan) for the donation of IVIG and Chong Dah Pharmaceuticals (Tainan, Taiwan) for the supply of l -ephedrine and Professor Y.C. Tong for editing. We thank Prof. David C.Y. Kwan of McMaster University for his help in the preparation of the final version of this manuscript. This work is supported in part by a grant from National Science Council (NSC87-2314-B006-104) of the Republic of China.",
year = "2001",
month = apr,
day = "12",
doi = "10.1016/S1566-0702(01)00225-9",
language = "English",
volume = "88",
pages = "1--5",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier B.V.",
number = "1-2",
}