@article{0b3035edd58748d49d9bfe889bd9f241,
title = "Stereoselective Synthesis Of Ribonucleoside 3{\textquoteright},5{\textquoteright}-Cyclic Methyl(Phenyl)Phosphonates And Phosphonothioates",
abstract = "Monophosphonylation of 2{\textquoteright}-protected ribonucleosides (i.e., 2{\textquoteright}-O-THP-uridine and 2{\textquoteright}-O-THP-N6-levulinoyl-adenosine) with the bifunctional reagents bis[( 6-trifluoromethyl)benzotriazol-1-yl] methyl(phenyl)phosphonates or the analogous phosphonothioates, and subsequent addition of N-methylimidazole gave the chirally pure {\textquoteleft},5{\textquoteright}methyl(phenyl)phosphonate or phosphonothioate derivatives, respectively. Deblocking of the fully protected compounds yielded, as evidenced by X-ray analysis. the corresponding pure Sp-diastereoisomers.",
author = "Roelen, {H. C.P.F.} and Vroom, {E. D.} and {Der Marel}, {G. A.V.} and Boom, {J. H.van} and Wang, {A. H.J.}",
note = "Funding Information: One of us, H.C.P.F. Roelen thanks the Netherlands Organization for Scientific Research (NWO) for financial support. Further we greatly acknowledge Mr. P.J.M. Van Haastert for the determination of chemotaxicity of the CAMP derivatives.",
year = "1992",
month = jan,
day = "1",
doi = "10.1080/07328319208021157",
language = "English",
volume = "11",
pages = "141--156",
journal = "Nucleosides and Nucleotides",
issn = "0732-8311",
publisher = "Taylor and Francis Ltd.",
number = "1",
}