TY - JOUR
T1 - Static magnetic field attenuates lipopolysaccharide-induced multiple organ failure
T2 - A histopathologic study in mice
AU - Lai, Wei Yi
AU - Huang, Yu Chih
AU - Chang, Wei Jen
AU - Wang, Hsin Ta
AU - Fong, Tsorng Harn
AU - Lin, Che Tong
AU - Huang, Haw Ming
N1 - Publisher Copyright:
© 2015 Informa UK, Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Purpose: Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ failure (MOF). Materials and methods: In this study, BALB/cByJNarl (5 weeks, weighing 20-25 g) mice were chosen as test subjects. The tested animals were challenged with 50 mg/kg LPS after they were exposed to a continuous SMF for 2 h. The survival rate and pathological changes in lungs, kidneys, and livers of the LPS- challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on body temperature control of the LPS-challenged mice were monitored. Results: Our results showed that at 30 h the survival rate of LPS-challenged mice increased 3.6-fold (p <0.05). In addition, 6 h after LPS injection, the average body temperature of SMF-exposed mice was 1.07°C lower than that of unexposed animals. Tissue biopsies demonstrated that SMF exposure reduced damage to the lungs, livers, and kidneys in the LPS-challenged mice. Conclusions: SMF show potential as a viable prophylactic alternative for controlling LPS-induced MOF.
AB - Purpose: Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ failure (MOF). Materials and methods: In this study, BALB/cByJNarl (5 weeks, weighing 20-25 g) mice were chosen as test subjects. The tested animals were challenged with 50 mg/kg LPS after they were exposed to a continuous SMF for 2 h. The survival rate and pathological changes in lungs, kidneys, and livers of the LPS- challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on body temperature control of the LPS-challenged mice were monitored. Results: Our results showed that at 30 h the survival rate of LPS-challenged mice increased 3.6-fold (p <0.05). In addition, 6 h after LPS injection, the average body temperature of SMF-exposed mice was 1.07°C lower than that of unexposed animals. Tissue biopsies demonstrated that SMF exposure reduced damage to the lungs, livers, and kidneys in the LPS-challenged mice. Conclusions: SMF show potential as a viable prophylactic alternative for controlling LPS-induced MOF.
KW - Histopathology
KW - Lipopolysaccharide
KW - Multiple organ failure
KW - Static magnetic field
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U2 - 10.3109/09553002.2015.959669
DO - 10.3109/09553002.2015.959669
M3 - Article
C2 - 25179347
AN - SCOPUS:84922883401
SN - 0955-3002
VL - 91
SP - 135
EP - 141
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 2
ER -