Spontaneous thought-related network connectivity predicts sertraline effect on major depressive disorder

Li Ming Hsu, Timothy Joseph Lane, Changwei W. Wu, Chien Yuan Lin, Chi Bin Yeh, Hung Wen Kao, Ching Po Lin

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)


Sertraline is one of the most commonly prescribed antidepressants. Major depressive disorder (MDD) is characterized by spontaneous thoughts that are laden with negative affect—a “malignant sadness”. Prior neuroimaging studies have identified abnormal resting-state functional connectivity (rsFC) in the spontaneous brain networks of MDD patients. But how antidepressant medication acts to relieve the experience of depression as well as adjust its associated spontaneous networks and mood-regulation circuits remains an open question. In this study, we recruited 22 drug-naïve MDD patients along with 35 normal controls and investigated whether the functional integrity of cortical networks associated with spontaneous thoughts is modulated by sertraline treatment. We attempted to predict post-treatment effects based upon what we observed in the pre-treatment rsFC of drug-naïve MDD patients. In the result, we demonstrated that (1) after the sertraline treatment, the medial temporal lobe of default network (DNMTL) and mood regulation pathway—the fronto-parietal control network (FPCN), the thalamus, and the salience network (SN)—were restored to normal connectivity, relative to the pre-treatment condition; however, the altered connections of FPCN-core DN (DNCORE), FPCN-SN, and intra-FPCN among MDD patients remained impaired; (2) thalamo-prefrontal connectivity provides moderate predictive power (r2 = 0.63) for the effectiveness of sertraline treatment. In summary, our findings contribute to a body of evidence that suggests salubrious effects of sertraline treatment primarily involve the FPCN-thalamus-SN pathway. The pre-treatment rsFC in this pathway could serve as a predictor of sertraline treatment outcome.

頁(從 - 到)1705-1717
期刊Brain Imaging and Behavior
出版狀態已發佈 - 8月 2021

ASJC Scopus subject areas

  • 放射學、核子醫學和影像學
  • 神經內科
  • 認知神經科學
  • 神經病學(臨床)
  • 細胞與分子神經科學
  • 精神病學和心理健康
  • 行為神經科學


深入研究「Spontaneous thought-related network connectivity predicts sertraline effect on major depressive disorder」主題。共同形成了獨特的指紋。