@article{a4895d29203842c6aca0c6cec28a031a,
title = "Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents",
abstract = "Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge Lendenfeldia sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (1-6). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by electronic circular dichroism (ECD) calculations. Compounds 2 and 3 were discovered to individually reduce the generation of superoxide anions, and compound 1 displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.",
keywords = "24-homoscalarane, anti-neutrophilic inflammation, elastase release, lendenfeldarane, Lendenfeldia, NADPH oxidase, sesterterpenoid, superoxide anion",
author = "Peng, {Bo Rong} and Lai, {Kuei Hung} and Chang, {Yu Chia} and Chen, {You Ying} and Su, {Jui Hsin} and Huang, {Yusheng M.} and Chen, {Po Jen} and Yu, {Steve Sheng Fa} and Duh, {Chang Yih} and Sung, {Ping Jyun}",
note = "Funding Information: Acknowledgments: This work was mainly supported by grants from the National Museum of Marine Biology and Aquarium; and the Ministry of Science and Technology (Grant Nos MOST 106-2320-B-291-001-MY3, 107-2320-B-291-001-MY3, and 109-2320-B-291-001-MY3), Taiwan, awarded to P.-J.S. Funding Information: Funding: The research was founded by the Ministry of Science and Technology of Taiwan (MOST 106-2320-B-291-001-MY3, 107-2320-B-291-001-MY3, and 109-2320-B-291-001-MY3). Publisher Copyright: {\textcopyright} 2020 MDPI AG. All rights reserved.",
year = "2020",
month = aug,
day = "19",
doi = "10.3390/md18090434",
language = "English",
volume = "18",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",
}
