TY - JOUR
T1 - Spinal cord injury and Alzheimer's disease risk
T2 - A population-based, retrospective cohort study article
AU - Yeh, Tian Shin
AU - Ho, Yu Chun
AU - Hsu, Cherng Lan
AU - Pan, Shin Liang
N1 - Funding Information:
Acknowledgements This work was supported by the Department of Health, Executive Yuan, Republic of China [DOH93-TD-M-113-030, DOH94-TD-M-113-004, and DOH95-TD-M-113-002].
Publisher Copyright:
© 2017 International Spinal Cord Society.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Study design: Propensity score-matched, retrospective cohort study. Objectives: To determine the risk of developing Alzheimer's disease (AD) in patients with spinal cord injury (SCI). Setting: The present study used Taiwan's National Health Insurance Research Database. Methods: A total of 9257 patients who had 2 ambulatory visits with a diagnosis of SCI in 2001 were included in the SCI group. The non-SCI group consisted of 37,028 propensity score-matched patients without a diagnosis of SCI. The cumulative incidence of AD was estimated for each of the two patient groups using the Kaplan-Meier method. Stratified Cox proportional hazard regression was then employed to assess the influence of SCI on the risk of AD. Results: During the follow-up period, 25 subjects in the SCI group and 57 in the non-SCI group developed AD. The cumulative incidence of AD in the SCI group was higher than in the non-SCI group (P = 0.0168); and the hazard ratio of AD for the SCI group, as compared to the non-SCI group, was 1.71 (95% CI 1.06-2.76, P = 0.0273). Conclusions: This study suggests that patients with SCI have an increased risk of developing AD.
AB - Study design: Propensity score-matched, retrospective cohort study. Objectives: To determine the risk of developing Alzheimer's disease (AD) in patients with spinal cord injury (SCI). Setting: The present study used Taiwan's National Health Insurance Research Database. Methods: A total of 9257 patients who had 2 ambulatory visits with a diagnosis of SCI in 2001 were included in the SCI group. The non-SCI group consisted of 37,028 propensity score-matched patients without a diagnosis of SCI. The cumulative incidence of AD was estimated for each of the two patient groups using the Kaplan-Meier method. Stratified Cox proportional hazard regression was then employed to assess the influence of SCI on the risk of AD. Results: During the follow-up period, 25 subjects in the SCI group and 57 in the non-SCI group developed AD. The cumulative incidence of AD in the SCI group was higher than in the non-SCI group (P = 0.0168); and the hazard ratio of AD for the SCI group, as compared to the non-SCI group, was 1.71 (95% CI 1.06-2.76, P = 0.0273). Conclusions: This study suggests that patients with SCI have an increased risk of developing AD.
UR - https://www.scopus.com/pages/publications/85031923473
UR - https://www.scopus.com/pages/publications/85031923473#tab=citedBy
U2 - 10.1038/s41393-017-0009-3
DO - 10.1038/s41393-017-0009-3
M3 - Article
C2 - 29057990
AN - SCOPUS:85031923473
SN - 1362-4393
VL - 56
SP - 151
EP - 157
JO - Spinal Cord
JF - Spinal Cord
IS - 2
ER -