Specific and Non-specific Clinical Presentations in the Year Before the Diagnosis of Childhood Leukaemia

Tien Yu Owen Yang, Yen Lin Liu, Wan Ting Huang, Mei Huei Chen, Pau Chung Chen

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)


Introduction: Clinical presentations of childhood leukaemia have been reported in case-only studies. The timing when these presentations start to occur prior to diagnosis is less clear. Methods: In this nested case–control study, 1,025 and 334 children with lymphoid and myeloid leukaemia, respectively, were matched (1:30) to population-based controls by sex, region and year of birth. An index date was assigned for each control when the matched case was diagnosed. Healthcare access records of cases and controls in the year before the index date were extracted. Results: Children with lymphoid leukaemia started to visit doctors more often at least 2 months before leukaemia diagnosis (P < 0.05). Various presentations were recorded in these visits: rates of haematological presentations, musculoskeletal presentations, and injuries started to increase significantly at least 3 months before diagnosis; rates of respiratory, gastrointestinal and urinary tract presentations did not increase significantly until the last month. The findings for myeloid lymphoma were less clear, but children appeared to visit doctors more often at least 4 months before diagnosis, and the rate of haematological presentations also started to increase at least 4 months before leukaemia diagnosis. Although haematological presentations were most strongly associated with undiagnosed leukaemia (odds ratio > 290 in the last month), the majority (>96%) of children with haematological presentations did not have leukaemia if they had not been diagnosed in their first visit. Conclusions: We described a clinical picture in the year before leukaemia diagnosis. These findings revealed ongoing difficulties in early diagnosis of childhood leukaemia in healthcare settings.
頁(從 - 到)1387-1393
期刊Pediatric Blood and Cancer
出版狀態已發佈 - 8月 1 2016

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康
  • 一般醫學
  • 血液學
  • 腫瘤科


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