Spatiotemporal dedifferentiation of the global brain signal topography along the adult lifespan

Yujia Ao, Chengxiao Yang, Jan Drewes, Muliang Jiang, Lihui Huang, Xiujuan Jing, Georg Northoff, Yifeng Wang

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Age-related variations in many regions and/or networks of the human brain have been uncovered using resting-state functional magnetic resonance imaging. However, these findings did not account for the dynamical effect the brain's global activity (global signal [GS]) causes on local characteristics, which is measured by GS topography. To address this gap, we tested GS topography including its correlation with age using a large-scale cross-sectional adult lifespan dataset (n = 492). Both GS topography and its variation with age showed frequency-specific patterns, reflecting the spatiotemporal characteristics of the dynamic change of GS topography with age. A general trend toward dedifferentiation of GS topography with age was observed in both spatial (i.e., less differences of GS between different regions) and temporal (i.e., less differences of GS between different frequencies) dimensions. Further, methodological control analyses suggested that although most age-related dedifferentiation effects remained across different preprocessing strategies, some were triggered by neuro-vascular coupling and physiological noises. Together, these results provide the first evidence for age-related effects on global brain activity and its topographic-dynamic representation in terms of spatiotemporal dedifferentiation.

原文英語
頁(從 - 到)5906-5918
頁數13
期刊Human Brain Mapping
44
發行號17
DOIs
出版狀態已發佈 - 12月 1 2023
對外發佈

ASJC Scopus subject areas

  • 解剖學
  • 放射與超音波技術
  • 放射學、核子醫學和影像學
  • 神經內科
  • 神經病學(臨床)

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