TY - JOUR
T1 - Size effect of colloidal selenium particles on the inhibition of LPS-induced nitric oxide production
AU - Chen, Yue-Hwa
AU - Chang, H. P.
AU - Lin, Zong Hong
AU - Wang, C. R Chris
PY - 2005
Y1 - 2005
N2 - We have stud led the size-dependent inhibition capabilities of colloidal selenium (Se) particles on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Four particle sizes of the nano-Se, ranging from 45-220 nm in diameter, were examined. All of them, unlike their bulk material, show clear capabilities of inhibition and a trend dependent on the particles size. The inhbition be comes more potent as the particle size in creases. It indicates that pursuing the reduction of colloidal sizes into nanoscale is not favoured in this biological system.
AB - We have stud led the size-dependent inhibition capabilities of colloidal selenium (Se) particles on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Four particle sizes of the nano-Se, ranging from 45-220 nm in diameter, were examined. All of them, unlike their bulk material, show clear capabilities of inhibition and a trend dependent on the particles size. The inhbition be comes more potent as the particle size in creases. It indicates that pursuing the reduction of colloidal sizes into nanoscale is not favoured in this biological system.
KW - NO radical inhibition
KW - Selenium nanoparticles
KW - Size-dependence
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U2 - 10.1002/jccs.200500058
DO - 10.1002/jccs.200500058
M3 - Article
AN - SCOPUS:33645416100
SN - 0009-4536
VL - 52
SP - 389
EP - 393
JO - Journal of the Chinese Chemical Society
JF - Journal of the Chinese Chemical Society
IS - 3
ER -