@article{3bd34aa224d74208b7bc3d1cd05241b0,
title = "Simultaneous splenectomy during liver transplantation augments anti-viral therapy in patients infected with hepatitis C virus",
abstract = "Background Simultaneous splenectomy in liver transplantation (LT) is selectively indicated because of splenoportal venous thromboses and increased sepsis. Therefore, its impact should be further investigated. Methods Of the 160 liver transplant patients, only 40 underwent simultaneous splenectomy. Clinicopathologic characteristics and outcomes were compared between the splenectomy and non-splenectomy group using retrospective analysis. Results Although the groups were similar and had no significant difference in the intra- and postoperative data, non-splenectomy group had more male patients. However, splenectomy group showed significantly higher platelet and leukocyte counts at 1 month and 6 months after the transplantation and higher hepatitis C virus anti-viral therapy completion. Furthermore, 3 patients developed portal or splenic vein thrombosis during the postoperative follow-up, but the overall survival rate did not significantly differ between these groups. Conclusion Simultaneous splenectomy in LT can be safely performed, particularly in patients with hepatitis C virus cirrhosis, small-for-size grafts, hypersplenism, and ABO blood group incompatible (ABO - incompatible) LT. {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
keywords = "Anti-viral therapy, Liver transplantation, Splenectomy, Splenectomy complication, Sustained viral response, interferon, ribavirin, alpha interferon, antivirus agent, macrogol derivative, peginterferon alpha2a, peginterferon alpha2b, recombinant protein, adult, antiviral therapy, Article, clinical feature, female, follow up, hepatitis C, Hepatitis C virus, human, leukocyte count, liver function, liver transplantation, major clinical study, male, overall survival, portal vein thrombosis, splenectomy, splenic vein, thrombocyte count, comparative study, complication, drug administration, drug combination, evaluation study, Hepatitis C, Chronic, hypersplenism, liver cirrhosis, middle aged, multimodality cancer therapy, retrospective study, treatment outcome, virology, Adult, Antiviral Agents, Combined Modality Therapy, Drug Administration Schedule, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Hypersplenism, Interferon-alpha, Liver Cirrhosis, Liver Transplantation, Male, Middle Aged, Polyethylene Glycols, Recombinant Proteins, Retrospective Studies, Ribavirin, Treatment Outcome",
author = "Heng-Cheng Chu and Chung-Bao Hsieh and Kuo-Feng Hsu and Hsiu-Lung Fan and Tsai-Yuan Hsieh and Teng-Wei Chen",
note = "Export Date: 22 March 2016 CODEN: AJSUA 通訊地址: Chen, T.-W.; Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Taiwan 化學物質/CAS: ribavirin, 36791-04-5; peginterferon alpha2a, 198153-51-4; peginterferon alpha2b, 215647-85-1; Antiviral Agents; Interferon-alpha; peginterferon alfa-2a; peginterferon alfa-2b; Polyethylene Glycols; Recombinant Proteins; Ribavirin 參考文獻: Starzl, T.E., Murase, N., Marcos, A., History of liver and multivisceral transplantation (2005) Transplantation of the Liver, pp. 3-22. , R.W. Busuttil, G.K. Klintmalm, 2nd ed. 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year = "2015",
doi = "10.1016/j.amjsurg.2014.03.004",
language = "English",
volume = "209",
pages = "180--186",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "1",
}
