Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Tsui Chin Huang; Hsin Yi Chang; Cheng Yu Chen; Pei Yi Wu; Hsinyu Lee; Yung Feng Liao; Wen Ming Hsu; Hsuan Cheng Huang; Hsueh Fen Juan

doi:10.1016/j.febslet.2011.10.025

Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Tsui Chin Huang, Hsin Yi Chang, Cheng Yu Chen, Pei Yi Wu, Hsinyu Lee, Yung Feng Liao, Wen Ming Hsu, Hsuan Cheng Huang, Hsueh Fen Juan

研究成果: 雜誌貢獻 › 文章 › 同行評審

66 引文斯高帕斯（Scopus）

摘要

Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.

原文	英語
頁（從 - 到）	3582-3586
頁數	5
期刊	FEBS Letters
卷	585
發行號	22
DOIs	https://doi.org/10.1016/j.febslet.2011.10.025
出版狀態	已發佈 - 11月 16 2011
對外發佈	是

ASJC Scopus subject areas

生物物理學
結構生物學
生物化學
分子生物學
遺傳學
細胞生物學

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10.1016/j.febslet.2011.10.025

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abstract = "Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.",

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AU - Huang, Tsui Chin

AU - Chang, Hsin Yi

AU - Chen, Cheng Yu

AU - Wu, Pei Yi

AU - Lee, Hsinyu

AU - Liao, Yung Feng

AU - Hsu, Wen Ming

AU - Huang, Hsuan Cheng

AU - Juan, Hsueh Fen

PY - 2011/11/16

Y1 - 2011/11/16

N2 - Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.

AB - Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.

KW - AHR

KW - Cell differentiation

KW - MicroRNA

KW - Neuroblastoma

KW - miR-124

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Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

摘要

ASJC Scopus subject areas

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