TY - JOUR
T1 - SHP2
T2 - The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis
AU - Chang, Chun Jung
AU - Lin, Chiou Feng
AU - Chen, Bing Chang
AU - Lin, Pei Yun
AU - Chen, Chia Ling
N1 - Funding Information:
This work was funded by the Ministry of Science and Technology of Taiwan (MOST107‐2320‐B‐038‐043‐MY3, MOST109‐2320‐B‐038‐070, and MOST110‐2314‐B‐038‐141) and Taipei Medical University (DP2‐110‐21121‐01‐T‐02‐02).
Publisher Copyright:
© 2021 International Union of Biochemistry and Molecular Biology
PY - 2022/2
Y1 - 2022/2
N2 - Chronic respiratory diseases (CRDs), including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), lung cancer, and asthma, are significant global health problems due to their prevalence and rising incidence. The roles of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) in controlling tyrosine phosphorylation of targeting proteins modulate multiple physiological cellular responses and contribute to the pathogenesis of CRDs. Src homology-2 domain-containing PTP2 (SHP2) plays a pivotal role in modulating downstream growth factor receptor signaling and cytoplasmic PTKs, including MAPK/ERK, PI3K/AKT, and JAK/STAT pathways, to regulate cell survival and proliferation. In addition, SHP2 mutation and activation are commonly implicated in tumorigenesis. However, little is known about SHP2 in chronic pulmonary inflammation and fibrosis. This review discusses the potential involvement of SHP2 deregulation in chronic pulmonary inflammation and fibrosis, as well as the therapeutic effects of targeting SHP2 in CRDs.
AB - Chronic respiratory diseases (CRDs), including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), lung cancer, and asthma, are significant global health problems due to their prevalence and rising incidence. The roles of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) in controlling tyrosine phosphorylation of targeting proteins modulate multiple physiological cellular responses and contribute to the pathogenesis of CRDs. Src homology-2 domain-containing PTP2 (SHP2) plays a pivotal role in modulating downstream growth factor receptor signaling and cytoplasmic PTKs, including MAPK/ERK, PI3K/AKT, and JAK/STAT pathways, to regulate cell survival and proliferation. In addition, SHP2 mutation and activation are commonly implicated in tumorigenesis. However, little is known about SHP2 in chronic pulmonary inflammation and fibrosis. This review discusses the potential involvement of SHP2 deregulation in chronic pulmonary inflammation and fibrosis, as well as the therapeutic effects of targeting SHP2 in CRDs.
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U2 - 10.1002/iub.2559
DO - 10.1002/iub.2559
M3 - Article
C2 - 34590785
AN - SCOPUS:85115947774
SN - 1521-6543
VL - 74
SP - 131
EP - 142
JO - IUBMB Life
JF - IUBMB Life
IS - 2
ER -
