摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 1340-1350 |
頁數 | 11 |
期刊 | Molecular Nutrition and Food Research |
卷 | 54 |
發行號 | 9 |
DOIs | |
出版狀態 | 已發佈 - 2010 |
對外發佈 | 是 |
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深入研究「Sesamin attenuates intercellular cell adhesion molecule-1 expression in vitro in TNF-α-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice」主題。共同形成了獨特的指紋。引用此
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於: Molecular Nutrition and Food Research, 卷 54, 編號 9, 2010, p. 1340-1350.
研究成果: 雜誌貢獻 › 文章 › 同行評審
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TY - JOUR
T1 - Sesamin attenuates intercellular cell adhesion molecule-1 expression in vitro in TNF-α-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice
AU - Wu, Wen-Huey
AU - Wang, Shu-Huei
AU - Kuan, I.-I.
AU - Kao, Ya-S.
AU - Wu, Pei-Jhen
AU - Liang, Chan-Jung
AU - Chien, Hsiung-Fei
AU - Kao, Chiu H.
AU - Huang, Ching-Jang
AU - Chen, Yuh-Lien
N1 - 被引用次數:10 Export Date: 16 March 2016 通訊地址: Chen, Y.-L.; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Ren-Ai Rd., Taipei 100, Taiwan; 電子郵件: [email protected] 化學物質/CAS: intercellular adhesion molecule 1, 126547-89-5; sesamin, 607-80-7, 7076-24-6; sesamol, 533-31-3; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Surface; Antioxidants; Apolipoproteins E; Benzodioxoles; Dioxoles; ELAV-like protein 1; Intercellular Adhesion Molecule-1, 126547-89-5; Lignans; Phenols; RNA, Messenger; RNA, Small Interfering; RNA-Binding Proteins; Tumor Necrosis Factor-alpha; sesamin, 607-80-7; sesamol, 533-31-3 參考文獻: Budowski, P., Markley, K.S., The chemical and physiological properties of sesame oil (1951) Chem. Rev, 48, pp. 125-151; Akimoto, K., Kitagawa, Y., Akamatsu, T., Hirose, N., Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents (1993) Ann. Nutr. Metab, 37, pp. 218-224; Hirose, N., Doi, F., Ueki, T., Akazawa, K., Suppressive effect of sesamin against 7,12-dimethylbenz-anthracene induced rat mammary carcinogenesis (1992) Anticancer Res, 12, pp. 1259-1265; Chavali, S.R., Zhong, W.W., Forse, R.A., Dietary alphalinolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: Effects of sesamin on the delta-5 desaturation of o6 and o3 fatty acids in mice (1998) Essent. Fatty Acids, 58, pp. 185-191. , Prostaglandins Leuko; Chavali, S.R., Utsunomiya, T., Forse, R.A., Increased survival after cecal ligation and puncture in mice consuming diets enriched with sesame seed oil (2001) Crit. Care Med, 29, pp. 140-143; Huo, R.C., Chen, H.L., Tzen, J.T., Jeng, K.C., Effect of sesame antioxidants on LPS-induced NO production by BV2 microglial cells (2003) Neuroreport, 14, pp. 1815-1819; Price, D.T., Loscalzo, J., Cellular adhesion molecules and atherogenesis (1999) Am. J. Med, 107, pp. 85-97; O'Brien, K.D., Allen, M.D., McDonald, T.O., Chait, A., Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis (1993) J. Clin. Invest, 92, pp. 945-951; Collins, T., Read, M.A., Neish, A.S., Whitley, M.Z., Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers (1995) FASEB J, 9, pp. 899-909; Muslin, A.J., J., MAPK signalling in cardiovascular health and disease: Molecular mechanisms and therapeutic targets (2008) Clin. Sci, 115, pp. 203-218; Lin, S.J., Shyue, S.K., Hung, Y.Y., Chen, Y.H., Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-a in human endothelial cells through the JNK/p38 pathways (2005) Arterioscler. Thromb. Vasc. Biol, 25, pp. 334-340; Brennan, C.M., Steitz, J.A., HuR and mRNA stability (2001) Cell. Mol. Life Sci, 58, pp. 266-277; Baud, V., Karin, M., Signal transduction by tumor necrosis factor and its relatives (2001) Trends Cell Biol, 11, pp. 372-377; Ghafoorunissa, H.S., Rao, M.V., Sesame lignans enhance antioxidant activity of vitamin E in lipid peroxidation systems (2004) Mol. Cell. Biochem, 262, pp. 195-202; Hsu, D.Z., Su, S.B., Chien, S.P., Chiang, P.J., Effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats: Involvement of nitric oxide and proinflammatory cytokines (2005) Shock, 24, pp. 276-280; Nakano, D., Kurumazuka, D., Nagai, Y., Nishiyama, A., Dietary sesamin suppresses aortic NADPH oxidase in DOCA salt hypertensive rats (2008) Clin. Exp. Pharmacol. Physiol, 35, pp. 324-326; Hirose, N., Inoue, T., Nishihara, K., Sugano, M., Inhibition of cholesterol absorption and synthesis in rats by sesamin (1991) J. Lipid Res, 32, pp. 629-638; Kiso, Y., Tsuruoka, N., Kidokoro, A., Matsumoto, I., Abe, K., Sesamin ingestion regulates the transcription levels of hepatic metabolizing enzymes for alcohol and lipids in rats (2005) Alcohol Clin. Exp. Res, 29, pp. 116S-120S; Hou, R.C., Huang, H.M., Tzen, J.T., Jeng, K.C., Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells (2003) J. Neurosci. Res, 74, pp. 123-133; Wu, W.H., Kang, Y.P., Wang, N.H., Jou, H.J., Wang, T.A., Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women (2006) J. Nutr, 136, pp. 1270-1275; Wertheimer, S.J., Myers, C.L., Wallace, R.W., Parks, T.P., Intercellular adhesion molecule-1 gene expression in human endothelial cells. Differential regulation by tumor necrosis factor-alpha and phorbol myristate acetate (1992) J. Biol. Chem, 267, pp. 12030-12035; Nabors, B.L., Suswan, E., Huang, Y., Yang, X., Tumor necrosis factor alpha induces angiogenic factor upregulation in malignant glioma cells: A role for RNA stabilization and HuR (2003) Cancer Res, 63, pp. 4181-4187; Jeng, K.C., Hou, R.C., Wang, J.C., Ping, L.I., Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB (2005) Immunol. Lett, 97, pp. 101-106; Hou, R.C., Wu, C.C., Yang, C.H., Jeng, K.C., Protective effects of sesamin and sesamolin on murine BV-2 microglia cell line under hypoxia (2004) Neurosci. Lett, 367, pp. 10-13; Ghosh, S., Baltimore, D., Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B (1990) Nature, 344, pp. 678-682; Bhaskaran, S., Santanam, N., Penumetcha, M., Parthasarathy, S., Inhibition of atherosclerosis in low-density lipoprotein receptor-negative mice by sesame oil (2006) J. Med. Food, 9, pp. 487-490; Utsunomiya, T., Chavali, S.R., Zhong, W.W., Forse, R.A., Effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor alpha in rats (2000) Am. J. Clin. Nutr, 72, pp. 804-808; Joris, I., Zand, T., Nunnari, J.J., Krolikowski, F.J., Majno, G., Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats (1983) Am. J. Pathol, 113, pp. 341-358
PY - 2010
Y1 - 2010
N2 - Sesame lignans have antioxidative and anti-inflammatory properties. We focused on the effects of the lignans sesamin and sesamol on the expression of endothelial-leukocyte adhesion molecules in tumor necrosis factor-α (TNF-α)-treated human aortic endothelial cells (HAECs). When HAECs were pretreated with sesamin (10 or 100 μM), the TNF-α-induced expression of intercellular cell adhesion molecule-1 (ICAM-1) was significantly reduced (35 or 70% decrease, respectively) by Western blotting. Sesamol was less effective at inhibiting ICAM-1 expression (30% decrease at 100 μM). Sesamin and sesamol reduced the marked TNF-α-induced increase in human antigen R (HuR) translocation and the interaction between HuR and the 3'UTR of ICAM-1 mRNA. Both significantly reduced the binding of monocytes to TNF-α-stimulated HAECs. Sesamin significantly attenuated TNF-α-induced ICAM-1 expression and cell adhesion by downregulation of extracellular signal-regulated kinase 1/2 and p38. Furthermore, in vivo, sesamin attenuated intimal thickening and ICAM-1 expression seen in aortas of apolipoprotein-E-deficient mice. Taken together, these data suggest that sesamin inhibits TNF-α -induced extracellular signal-regulated kinase/p38 phosphorylation, nuclear translocation of NF-κB p65, cytoplasmic translocalization of HuR and thereby suppresses ICAM-1 expression, resulting in reduced adhesion of leukocytes. These results also suggest that sesamin may prevent the development of atherosclerosis and inflammatory responses. © 2010 WILEY-VCH Verlag GmbH & Co.
AB - Sesame lignans have antioxidative and anti-inflammatory properties. We focused on the effects of the lignans sesamin and sesamol on the expression of endothelial-leukocyte adhesion molecules in tumor necrosis factor-α (TNF-α)-treated human aortic endothelial cells (HAECs). When HAECs were pretreated with sesamin (10 or 100 μM), the TNF-α-induced expression of intercellular cell adhesion molecule-1 (ICAM-1) was significantly reduced (35 or 70% decrease, respectively) by Western blotting. Sesamol was less effective at inhibiting ICAM-1 expression (30% decrease at 100 μM). Sesamin and sesamol reduced the marked TNF-α-induced increase in human antigen R (HuR) translocation and the interaction between HuR and the 3'UTR of ICAM-1 mRNA. Both significantly reduced the binding of monocytes to TNF-α-stimulated HAECs. Sesamin significantly attenuated TNF-α-induced ICAM-1 expression and cell adhesion by downregulation of extracellular signal-regulated kinase 1/2 and p38. Furthermore, in vivo, sesamin attenuated intimal thickening and ICAM-1 expression seen in aortas of apolipoprotein-E-deficient mice. Taken together, these data suggest that sesamin inhibits TNF-α -induced extracellular signal-regulated kinase/p38 phosphorylation, nuclear translocation of NF-κB p65, cytoplasmic translocalization of HuR and thereby suppresses ICAM-1 expression, resulting in reduced adhesion of leukocytes. These results also suggest that sesamin may prevent the development of atherosclerosis and inflammatory responses. © 2010 WILEY-VCH Verlag GmbH & Co.
KW - Atherosclerosis
KW - Endothelial cell
KW - Intercellular cell adhesion molecule-1
KW - NF-κb
KW - Sesamin
KW - 1,3 benzodioxole derivative
KW - 1,3 dioxolane derivative
KW - antioxidant
KW - apolipoprotein E
KW - ELAV-like protein 1
KW - HuR protein
KW - intercellular adhesion molecule 1
KW - lignan
KW - membrane antigen
KW - messenger RNA
KW - nonsteroid antiinflammatory agent
KW - phenol derivative
KW - RNA binding protein
KW - sesamin
KW - sesamol
KW - small interfering RNA
KW - tumor necrosis factor alpha
KW - animal
KW - aorta
KW - article
KW - atherosclerosis
KW - cell culture
KW - cell line
KW - comparative study
KW - cytology
KW - drug effect
KW - gene expression regulation
KW - genetics
KW - human
KW - metabolism
KW - monocyte
KW - mouse
KW - mouse mutant
KW - pathology
KW - randomization
KW - signal transduction
KW - vascular endothelium
KW - Animals
KW - Anti-Inflammatory Agents, Non-Steroidal
KW - Antigens, Surface
KW - Antioxidants
KW - Aorta
KW - Apolipoproteins E
KW - Benzodioxoles
KW - Cell Line
KW - Cells, Cultured
KW - Dioxoles
KW - Endothelium, Vascular
KW - Gene Expression Regulation
KW - Humans
KW - Intercellular Adhesion Molecule-1
KW - Lignans
KW - Mice
KW - Mice, Knockout
KW - Monocytes
KW - Phenols
KW - Random Allocation
KW - RNA, Messenger
KW - RNA, Small Interfering
KW - RNA-Binding Proteins
KW - Signal Transduction
KW - Tumor Necrosis Factor-alpha
KW - Mus
KW - Sesamum indicum
U2 - 10.1002/mnfr.200900271
DO - 10.1002/mnfr.200900271
M3 - Article
SN - 1613-4125
VL - 54
SP - 1340
EP - 1350
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 9
ER -