Self-assembled binary colloidal crystal monolayers as cell culture substrates

Peng Yuan Wang, Hitesh Pingle, Peter Koegler, Helmut Thissen, Peter Kingshott

研究成果: 雜誌貢獻文章同行評審

48 引文 斯高帕斯(Scopus)


This study investigated the formation of self-assembled binary colloidal crystal (BCC) monolayers using evaporation induced confined area assembly (EICAA), and fabricated a family of various BCCs for cell culture. A library of various BCCs with different structures was established and it was demonstrated that after stabilisation the BCCs have potential to be used as substrates with well-ordered surface topographies and chemistries for manipulating cell-surface interactions. Three cell types including MG63 osteoblasts, L929 fibroblasts, and primary human adipose-derived stem cells (hADSCs) show different responses on selected surfaces (either between BCCs or BCCs vs. flat controls). In general, cell spreading was inhibited on BCCs due to surface topography. However, the chemical composition presented on the BCCs can compensate the topographic effect depending on what combination was used. The ordered topographic and heterogeneous chemical patterns provide a complexity of surface properties and have potential to be selectively modified with desired biomolecules for controlling biointerface interactions.
頁(從 - 到)2545-2552
期刊Journal of Materials Chemistry B
出版狀態已發佈 - 3月 28 2015

ASJC Scopus subject areas

  • 生物醫學工程
  • 一般醫學
  • 一般化學
  • 一般材料科學


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