@article{e19055200f834fc49f206758efd8878f,
title = "Selective COX-2 inhibitors. Part 1: Synthesis and biological evaluation of phenylazobenzenesulfonamides",
abstract = "A series of phenylazobenzenesulfonamide derivatives were designed and synthesized for the evaluation as selective cyclooxygenase-2 (COX-2) inhibitors in a cellular assay using human whole blood (HWB) and an enzymatic assay using purified ovine enzymes. Extensive structure-activity relationships (SAR) were studied within this series, and several of selective COX-2 inhibitors have been identified. Among them, compound 8, 4-(4-amino-2-methylsulfanyl-phenylazo)benzenesulfonamide, showed a potent inhibitory activity to the cyclooxygenase enzymes (IC50's for COX-1: 23.28 μM; COX-2: 2.04 μM), being active but less COX-2 selective than celecoxib.",
keywords = "Anti-inflammatory, Isosterism, Phenylazobenzenesulfonamide, Resveratrol, SAR, Selective COX-2 inhibitors",
author = "Tsai, {Wei Jern} and Shiao, {Young Ji} and Lin, {Shwu Jiuan} and Chiou, {Wen Fei} and Lin, {Lie Chwen} and Yang, {Tsang Hsiung} and Teng, {Che Ming} and Wu, {Tain Shung} and Yang, {Li Ming}",
note = "Funding Information: We gratefully thank the National Science Council of Republic of China Grants NSC-94-2320-B-077-005 (L.-M.Y.) and NSC-94-2320-B-038-030 (S.-J.L.), and National Research Institute of Chinese Medicine for research funding (Grant NRICM-95-DMC-007).",
year = "2006",
month = sep,
day = "1",
doi = "10.1016/j.bmcl.2006.06.036",
language = "English",
volume = "16",
pages = "4440--4443",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ireland Ltd",
number = "17",
}