Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan

Yun Pung P. Hsu, See Voon Seow, El Wei Loh, Yuan Chun Wang, Chiao Chicy Chen, Jeng Ming Yu, Andrew T.a. Cheng

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

The alternatively spliced 8-amino-acid exon for the GABA(A) receptor γ2 subunit gene (GABRC2) has been postulated to mediate behavioral actions of alcohol. A rapid search for splice-junction mutations near the 8-amino-acid exon using restriction enzymes which normally recognize sequences near or in the exon gave negative results among 217 alcoholics in four aboriginal groups (Ami, Atayal, Bunun and Paiwan) and Han Chinese in Taiwan. The role of the GABRC2 gene in alcoholism was further assessed by a comparison of allelic frequencies revealed by a NciI RFLP between case and control groups. No significant association of alcohol dependence with GABRC2 alleles was observed. These results suggest that the GABRC2 gene probably does not play an essential role in predisposition to alcoholism in the sample population.
原文英語
頁(從 - 到)284-286
頁數3
期刊Molecular Brain Research
56
發行號1-2
DOIs
出版狀態已發佈 - 5月 1 1998
對外發佈

ASJC Scopus subject areas

  • 分子生物學
  • 細胞與分子神經科學

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