@article{e8fd242d94cf47d4af89228cb32c0258,
title = "Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan",
abstract = "In the present study an immunofluorescence using KH-2 cells as target cells, has been developed for the screening of 1200 serum samples from normal individuals and 450 of cases from patients with various malignancies. The positive anti-HTLV-I antibody rate in the former group is 0.083%(1/1200) and while in the latter it is found to be 1.8%(8/450) (including 3 adult T-cell leukemia/lymphoma cases of the 92 hematopoietic and 5 of 358 non-hematopoietic malignancies). The differences between the two groups are found to be significantly different (p value is <0.0001). In addition to the 3 adult T-cell leukemia/lymphoma cases, the 5 seropositive cancer patients are of 5 different diseases. We have searched for the adult T-cell leukemia virus antigen and the p19 core protein in lymphoid cells of seropositive persons and the only positive cases were from cells of two proven adult T-cell leukemia (ATL) patients. Our results suggest that Taiwan is not an endemic area of adult T-cell leukemia virus and that KH-2 cells may be used for the detection of anti-HTLV-I antibodies.",
keywords = "anti-HTLV-I antibody, ATLV, hematologic malignancy, HTLV-I, KH-2 cell line, p24 core protein",
author = "Chen, {Po Min} and Chiu, {Chang Fang} and Chiou, {Tzeon Jye} and Tzeng, {Cheng Hwai} and Lin, {Sun Tien} and Wang, {Lih Shinn} and Yeh Lee and Chien, {Kwang Yu} and Chang, {Sien Shih} and Sakan Maeda and Blattner, {William A.} and Chiang, {Benjamin N.} and Greaves, {Melvyn F.}",
note = "Funding Information: Acknowledgements--This work was supported by grants from the Clinical Research Center, Institute of Biomedical Sciences, Academia Sinica and National Science Council of the Republic of China.",
year = "1986",
doi = "10.1016/0145-2126(86)90065-2",
language = "English",
volume = "10",
pages = "369--373",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Ltd",
number = "4",
}
