@inproceedings{c2d8de8ad9e941e2931af0f33f2107b3,
title = "Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring",
abstract = "In the present study, we indicated that the detection of specific subtypes of circulating tumor microemboli (CTM) in post-operative patients could help predict cancer recurrence. By using conventional strategies for detection of non-small-cell lung cancer (NSCLC) circulating tumor cells, is significantly limited due to inherently heterogeneous and dynamic expression of EpCAM, and degradation of cytokeratins during epithelial-tomesenchymal transition. These lead to non-negligible false negative detection of “uncapturable and invisible” single CTCs. To solve the problem, we investigated the clinical significance of CTM subtypes, including single CTCs, multi-CTCs cluster, and WBC-CTCs cluster on SACA chip for studying cancer metastasis and recurrence in patients with lung adenocarcinoma.",
keywords = "Circulating Tumor Cell Clusters, Immunotherapy, Non-small-cell lung cancer (NSCLC)",
author = "Hsu, {Chun Jieh} and Kan, {Yu Chia} and Lee, {Chun Wei} and Wu, {Jen Kuei} and Lee, {Kang Yun} and Feng, {Po Hao} and Chang, {Wei Chiao} and Tseng, {Fan Gang}",
note = "Publisher Copyright: {\textcopyright} 2020 CBMS-0001 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
year = "2020",
language = "English",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1141--1142",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}
