S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh; Tzung Sheng Lin; Hsiao Wen Wang; Hou Wen Cheng; Der Zen Liu; Pi Hui Liang

doi:10.1039/c5ob01376c

S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh, Tzung Sheng Lin, Hsiao Wen Wang, Hou Wen Cheng, Der Zen Liu, Pi Hui Liang

研究成果: 雜誌貢獻 › 文章 › 同行評審

17 引文斯高帕斯（Scopus）

摘要

An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

原文	英語
頁（從 - 到）	11518-11528
頁數	11
期刊	Organic and Biomolecular Chemistry
卷	13
發行號	47
DOIs	https://doi.org/10.1039/c5ob01376c
出版狀態	已發佈 - 2015

ASJC Scopus subject areas

生物化學
物理與理論化學
有機化學

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10.1039/c5ob01376c

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AU - Yeh, Hsien Wei

AU - Lin, Tzung Sheng

AU - Wang, Hsiao Wen

AU - Cheng, Hou Wen

AU - Liu, Der Zen

AU - Liang, Pi Hui

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

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Y1 - 2015

N2 - An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

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S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

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